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Antidepressant-associated sexual dysfunction: impact, effects, and treatment

Authors Higgins A, Nash M, Lynch AM

Published 9 September 2010 Volume 2010:2 Pages 141—150

DOI https://doi.org/10.2147/DHPS.S7634

Review by Single-blind

Peer reviewer comments 3


Agnes Higgins, Michael Nash, Aileen M Lynch
School of Nursing and Midwifery Studies, Trinity College Dublin, Dublin, Ireland

Abstract: Sexual dysfunction is a common side effect of antidepressants and can have significant impact on the person’s quality of life, relationships, mental health, and recovery. The reported incidence of sexual dysfunction associated with antidepressant medication varies considerably between studies, making it difficult to estimate the exact incidence or prevalence. The sexual problems reported range from decreased sexual desire, decreased sexual excitement, diminished or delayed orgasm, to erection or delayed ejaculation problems. There are a number of case reports of sexual side effects, such as priapism, painful ejaculation, penile anesthesia, loss of sensation in the vagina and nipples, persistent genital arousal and nonpuerperal lactation in women. The focus of this article is to explore the incidence, pathophysiology, and treatment of antidepressant iatrogenic sexual dysfunction.

Keywords: depression, antidepressant, iatrogenic sexual dysfunction, SSRI, SNRI

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