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Animal models of ulcerative colitis and their application in drug research

Authors Low D, Nguyen DD, Mizoguchi E

Received 23 August 2013

Accepted for publication 3 October 2013

Published 12 November 2013 Volume 2013:7 Pages 1341—1357

DOI https://doi.org/10.2147/DDDT.S40107

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Daren Low,1 Deanna D Nguyen,1,2 Emiko Mizoguchi1,2

1Gastrointestinal Unit, Department of Medicine, 2Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

Abstract: The specific pathogenesis underlying inflammatory bowel disease is complex, and it is even more difficult to decipher the pathophysiology to explain for the similarities and differences between two of its major subtypes, Crohn's disease and ulcerative colitis (UC). Animal models are indispensable to pry into mechanistic details that will facilitate better preclinical drug/therapy design to target specific components involved in the disease pathogenesis. This review focuses on common animal models that are particularly useful for the study of UC and its therapeutic strategy. Recent reports of the latest compounds, therapeutic strategies, and approaches tested on UC animal models are also discussed.

Keywords: inflammatory bowel disease, preclinical trials, emerging therapy

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