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Angiotensin II receptor blockers in the prevention of complications from atrial fibrillation

Authors Eide S, Peacock F

Published 11 September 2009 Volume 2009:5 Pages 783—791

DOI https://doi.org/10.2147/VHRM.S7616

Review by Single-blind

Peer reviewer comments 2


Gerald V Naccarelli,1 Frank Peacock2

1Penn State Heart and Vascular institute, Hershey, Pennsylvania, USA; 2Cleveland Clinic, Cleveland, Ohio, USA

Abstract: Atrial fibrillation (AF) is the most common form of cardiac arrhythmia and is associated with an increased risk of cardiovascular morbidity and mortality, especially due to ischemic stroke. The occurrence of AF leads to atrial electrical and structural remodeling. The renin-angiotensin system appears to play a role in the development of atrial arrhythmias by its involvement in both of these processes. Large-scale hypertension trials and heart failure trials have indicated the potential value of angiotensin II receptor blockers in the treatment of AF.

Keywords: angiotensin II receptor blockers, atrial fibrillation, cardiac arrhythmia

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