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Anesthesia Options and the Recurrence of Cancer: What We Know so Far?

Authors Cata JP, Guerra C, Soto G, Ramirez MF

Received 19 March 2020

Accepted for publication 23 June 2020

Published 7 July 2020 Volume 2020:13 Pages 57—72

DOI https://doi.org/10.2147/LRA.S240567

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Stefan Wirz


Juan P Cata,1,2 Carlos Guerra,3 German Soto,4 Maria F Ramirez1,2

1Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 2Anesthesiology and Surgical Oncology Research Group, Houston, TX, USA; 3Department of Anesthesia, Pain Management, and Perioperative Medicine, Henry Ford Hospital, Detroit, MI, USA; 4Department of Anesthesiology, Hospital Eva Perón, Rosario, Santa Fe, Argentina

Correspondence: Juan P Cata
Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Centre, 1515 Holcombe Blvd., Unit 409, Houston, TX 77005, USA
Tel/Fax +1 713-792-4582
Email JCata@mdanderson.org

Abstract: Surgery is a critical period in the survival of patients with cancer. While resective surgery of primary tumors has shown to prolong the life of these patients, it can also promote mechanisms associated with metastatic progression. During surgery, patients require general and sometimes local anesthetics that also modulate mechanisms that can favor or reduce metastasis. In this narrative review, we summarized the evidence about the impact of local, regional and general anesthesia on metastatic mechanisms and the survival of patients. The available evidence suggests that cancer recurrence is not significantly impacted by neither regional anesthesia nor volatile or total intravenous anesthesia.

Keywords: neoplasm, surgery, anesthesia, recurrence

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