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Analysis of the Risk Factors for Nosocomial Bacterial Infection in Patients with COVID-19 in a Tertiary Hospital

Authors Cheng K, He M, Shu Q, Wu M, Chen C, Xue Y

Received 26 August 2020

Accepted for publication 23 October 2020

Published 13 November 2020 Volume 2020:13 Pages 2593—2599

DOI https://doi.org/10.2147/RMHP.S277963

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Marco Carotenuto


Keping Cheng,1 Miao He,2 Qin Shu,3 Ming Wu,3 Cuifang Chen,2 Yulei Xue4

1Department of Infection Management, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, People’s Republic of China; 2Department of Public Health, Huangshi Central Hospital, Huangshi 435000, People’s Republic of China; 3Department of Infection Prevention and Control, Huangshi Traditional Chinese Medicine Hospital, Huangshi 435004, Republic of China; 4Department of Infectious Diseases, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing 210029, People’s Republic of China

Correspondence: Keping Cheng
Zhongda Hospital Affiliated to Southeast University, No. 87 Dingjiaqiao, Nanjing, People’s Republic of China
Email [email protected]

Background: Infection surveillance and risk factor analysis are among the most important prerequisites for the prevention and treatment of nosocomial bacteria infections, which are the demands for both infected and non-infected patients.
Purpose: To explore the risk factors for nosocomial bacterial infection of patients with COVID-19, and further to provide a theoretical basis for scientific prevention and control of nosocomial bacterial infection.
Methods: Between 10 January 2020 and 9 March 2020, we collected data of 212 patients with COVID-19 and then explored the influence of age, gender, length of stay, use of ventilator, urinary catheterization, central venous catheterization, white blood cell (WBC) count and procalcitonin on the nosocomial bacterial infection of patients with COVID-19 by a retrospective study.
Results: There were 212 confirmed cases of COVID-19, of which 31 cases had nosocomial bacterial infections, with an incidence of 14.62%. The most common types of nosocomial bacterial infections were lower respiratory tract (12 cases, 38.71%), which was the most frequent site, followed by urinary tract (10 cases, 32.26%), blood stream (7 cases, 22.58%), upper respiratory tract (1 case, 3.23%) and gastrointestinal tract infection (1 case, 3.23%). The incidence of nosocomial bacterial infection was significantly correlated with age, arteriovenous catheterization, urinary catheterization, WBC count and procalcitonin. Moreover, multivariate analysis confirmed that WBC (OR 8.38, 95% CI 1.07 to 65.55), procalcitonin (OR 4.92, 95% CI 1.39 to 17.33) and urinary catheterization (OR 25.38, 95% CI 5.09 to 126.53) were independent risk factors for the nosocomial bacterial infection of patients with COVID-19.
Conclusion: Understanding the risk factors for nosocomial bacterial infection of patients with COVID-19 and strengthening the monitoring of various susceptible factors are helpful to control the occurrence of nosocomial bacterial infection in the COVID-19 isolation wards.

Keywords: COVID-19, nosocomial bacterial infection, risk factor

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