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Analysis of Symptoms of COVID-19 Positive Patients and Potential Effects on Initial Assessment

Authors Korell F, Giannitsis E, Merle U, Kihm LP

Received 11 August 2020

Accepted for publication 27 October 2020

Published 3 December 2020 Volume 2020:12 Pages 451—457


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Hans-Christoph Pape

Felix Korell,1,2 Evangelos Giannitsis,3 Uta Merle,4 Lars Philipp Kihm1,5

1Casualty Department, University Hospital Heidelberg, Heidelberg, Germany; 2Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany; 3Department of Internal Medicine III, University Hospital Heidelberg, Heidelberg, Germany; 4Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany; 5Department of Internal Medicine I, University Hospital Heidelberg, Heidelberg, Germany

Correspondence: Felix Korell
University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Tel +49 6221567989
Email [email protected]

Background: SARS-CoV-2 is a highly contagious virus, significantly impacting Germany among other countries since its emergence. Because of heterogeneous symptoms and a subset of patients even being asymptomatic at presentation, fast identification of infected patients remains challenging.
Objective: The goal of this study is the evaluation of different patient groups with a focus on symptoms and pre-existing illness at admission, as this is important for initial assessment and adequate emergency care.
Methods: COVID-19 positive patients at the University Hospital Heidelberg were retrospectively analyzed for disease history and symptoms at the initial presentation as well as mortality. The authors obtained institutional review board (IRB) approval by the Ethics Committee (Medical Faculty of Heidelberg University) prior to commencing the study.
Results: Dyspnea was more common in patients admitted to intermediate care/intensive care units (48 vs 13%, P< 0.001) and showed a significantly higher percentage in the deceased (91 vs 48%, P=0.004). The symptoms of all presenting patients were highly variable, and many manifestations commonly associated with COVID-19 like cough, fever, and sore throat were only detected in a subset of patients, 60%, 43%, and 33%, respectively.
Conclusion: Dyspnea was present significantly more often in patients dying of COVID-19 compared to all patients admitted to the IMC/ICU, necessitating adequate observation and monitoring. In all presenting patients, initial symptoms showed large variation; therefore, COVID should be considered as a main differential diagnosis at every patient presentation, and patients with high pre-test probability should, if possible, be isolated until testing results are known.

Keywords: COVID-19, dyspnea, mortality, triage

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