Back to Journals » Clinical Pharmacology: Advances and Applications » Volume 2

Analgesic efficacy of oral gabapentin added to standard epidural corticosteroids in patients with failed back surgery

Authors Zencirci B

Published 30 September 2010 Volume 2010:2 Pages 207—211


Review by Single-blind

Peer reviewer comments 3

Beyazit Zencirci

Department of Anesthesiology and Reanimation, Medical Faculty of Sutcu Imam University, Kahramanmaras, Turkey

Objective: Failed back surgery syndrome is characterized by the presence of intractable pain and varying degrees of functional incapacity after lumbar spine surgery. Because the mechanisms that cause pain are variable, treatment of this syndrome is quite difficult, and one of the most common methods that is used for treatment nowadays is epidural injection. This research evaluates the analgesic efficacy of addition of oral gabapentin treatment to epidural corticosteroid application in patients with failed back surgery syndromes.

Methods: Forty-two patients, including 23 females and 19 males, with failed back surgery syndrome who had been previously operated on at least twice due to lumbar disc herniation were randomly divided into two groups. Following epidural application of a single dose of methylprednisolone in the first group of patients (Group K), an oral medical treatment containing naproxen sodium, tizanidine, and vitamin B and C complex, was devised to be applied for one month. For the second group, oral gabapentin was added to the same treatment regime (Group G). Pain levels were evaluated by a visual analog scale for straight leg raise before, during, and after treatment, as well as in the first and third months.

Results: There was no demographically significant difference between the patients (P > 0.05). After the beginning of treatment, it was observed that the pain level in Group G patients regressed earlier and that it progressed at a significantly lower level (both in the first and third month controls).

Conclusion: It was concluded that addition of oral gabapentin to epidural corticosteroid application in patients with failed back surgery syndromes was effective in ameliorating pain at an early stage without significant side effects.
Keywords: failed back surgery syndrome, epidural corticosteroid, gabapentin

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other articles by this author:

Sertraline-induced pseudocholinesterase enzyme deficiency

Beyazit Zencirci

International Journal of General Medicine 2010, 3:375-378

Published Date: 16 November 2010

Marfan syndrome with acute abdomen: a case report

Beyazit Zencirci

International Journal of General Medicine 2010, 3:359-363

Published Date: 10 November 2010

Comparison of the effects of dietary factors in the management and prophylaxis of migraine

Beyazit Zencirci

Journal of Pain Research 2010, 3:125-130

Published Date: 23 July 2010

Postdural puncture headache and pregabalin

Beyazit Zencirci

Journal of Pain Research 2010, 3:11-14

Published Date: 25 February 2010

Readers of this article also read:

Emerging and future therapies for hemophilia

Carr ME, Tortella BJ

Journal of Blood Medicine 2015, 6:245-255

Published Date: 3 September 2015

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010