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An update on the surgical management of pterygium and the role of loteprednol etabonate ointment

Authors Sheppard J, Mansur A, Comstock TL, Hovanesian J

Received 2 October 2013

Accepted for publication 19 December 2013

Published 13 June 2014 Volume 2014:8 Pages 1105—1118

DOI https://doi.org/10.2147/OPTH.S55259

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


John D Sheppard,1 Arnulfo Mansur,2 Timothy L Comstock,3 John A Hovanesian4

1Virginia Eye Consultants, Norfold, VA, USA; 2Airala's Laser and Cataract Institute, Miami, FL, USA; 3Bausch and Lomb, Inc., Rochester, NY, USA; 4Harvard Eye Associates, Laguna Hills, CA, USA

Abstract: Pterygium, a sun-related eye disease, presents as wing-shaped ocular surface lesions that extend from the bulbar conjunctiva onto the cornea, most commonly on the nasal side. Pterygia show characteristic histological features that suggest that inflammation plays a prominent role in their initial pathogenesis and recurrence. Appropriate surgery is the key to successful treatment of pterygia, but there is also a rationale for the use of anti-inflammatory agents to reduce the rate of recurrence following surgery. Multiple surgical techniques have been developed over the last two millennia, but these initially had little success, due to high rates of recurrence. Current management strategies, associated with lower recurrence rates, include bare sclera excision and various types of grafts using tissue glues. Adjunctive therapies include mitomycin C and 5-fluorouracil, as well as the topical ocular steroid loteprednol etabonate, which has been shown to have a lower risk of elevated intraocular pressure than have the other topical ocular steroids. Here, the surgical management of pterygium is presented from a historical perspective, and current management techniques, including the appropriate use of various adjunctive therapies, are reviewed, along with an illustrative case presentation and a discussion of the conjunctival forceps designed to facilitate surgical management. Despite thousands of years of experience with this condition, there remains a need for a more thorough understanding of pterygium and interventions to reduce both its incidence and postsurgical recurrence. Until that time, the immediate goal is to optimize surgical practices to ensure the best possible outcomes. Loteprednol etabonate, especially the ointment formulation, appears to be a safe and effective component of the perioperative regimen for this complex ocular condition, although confirmatory prospective studies are needed.

Keywords: mitomycin C, recurrence, surgical management, 5-fluorouracil, pterygium, loteprednol etabonate

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