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AMPK in the central nervous system: physiological roles and pathological implications

Authors Rosso P, Fioramonti M, Fracassi A, Marangoni M, Taglietti V, Siteni S, Segatto M

Received 14 October 2015

Accepted for publication 30 November 2015

Published 29 January 2016 Volume 2016:7 Pages 1—13

DOI https://doi.org/10.2147/RRB.S90858

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Pan Li

Peer reviewer comments 4

Editor who approved publication: Professor Zvi Kelman

Pamela Rosso,1,2,* Marco Fioramonti,3,* Anna Fracassi,2 Martina Marangoni,4 Valentina Taglietti,5 Silvia Siteni,2,6 Marco Segatto5

1Institute of Cell Biology and Neurobiology, National Research Council (CNR), 2Department of Sciences, University of Rome “Roma Tre”, 3Laboratory of Translational Oncology, University Campus Bio-Medico of Rome, 4Medical Genetics Unit, University Hospital of Rome “Tor Vergata”, Rome, 5Department of Biosciences, University of Milan, Milan, 6Department of Experimental Oncology, Regina Elena National Cancer Institute, Rome, Italy

*These authors contributed equally to this work

Abstract: 5′ AMP-activated protein kinase (AMPK) is considered the master metabolic regulator in all eukaryotes, as it maintains cellular energy homeostasis in a variety of tissues, including the brain. In humans, alterations in AMPK activity can lead to a wide spectrum of metabolic disorders. The relevance of this protein kinase in the pathogenesis of diabetes and metabolic syndrome is now well established. On the contrary, correlations between AMPK and brain physiopathology are still poorly characterized. The aim of this review is to summarize and discuss the current knowledge about the prospective involvement of AMPK in the onset and the progression of different neurological diseases.

Keywords: AMPK, brain, neurodegeneration, stroke, tumor, autophagy

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