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Amniotic membrane extract and eye drops: a review of literature and clinical application

Authors Murri MS, Moshirfar M, Birdsong OC, Ronquillo YC, Ding YN, Hoopes PC

Received 14 February 2018

Accepted for publication 17 April 2018

Published 18 June 2018 Volume 2018:12 Pages 1105—1112


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Michael S Murri,1 Majid Moshirfar,1,2 Orry C Birdsong,2 Yasmyne C Ronquillo,2 Yanning Ding,2 Phillip C Hoopes2

1John A Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA; 2HDR Research Center, Hoopes Vision, Draper, UT, USA

Abstract: The amniotic membrane (AM) has a long history of use in the treatment of various diseases of the ocular surface. It contains pluripotent cells, highly organized collagen, anti-fibrotic and anti-inflammatory cytokines, immune-modulators, growth factors, and matrix proteins. It is used to promote corneal healing in severely damaged eyes. Recently, AM extract and AM extract eye drops have been successfully used in clinical applications, including dry eye and chemical burns. We provide an overview on the recent progress in the preparation, mechanisms of action, and use of AM extract/AM extract eye drops for corneal and external eye diseases.

Keywords: amniotic membrane, amniotic membrane extract, amniotic membrane extract eye drops, AME, AMEED, AMT, umbilical cord, amnion, Regenesol, Genesis, Regener-Eyes, corneal wound healing, amniotic membrane transplant

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