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Alitretinoin for the treatment of severe chronic hand eczema

Authors King T, McKenna J, Alexandroff A

Received 19 November 2013

Accepted for publication 26 February 2014

Published 25 November 2014 Volume 2014:8 Pages 1629—1634

DOI https://doi.org/10.2147/PPA.S38830

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Thomas King, John McKenna, Anton B Alexandroff

Department of Dermatology, University Hospitals of Leicester, Leicester Royal Infirmary, Leicester, UK

Abstract: Chronic hand eczema is a common and often debilitating condition. Alitretinoin, a 9-cis-retinoic acid and pan-retinoic acid agonist, is a new and effective systemic treatment for chronic hand eczema, which provides another treatment option. A “clear” or “almost clear” response can be achieved in up to half of patients within a 24-week course of treatment. Even higher rates of remission can be obtained with a longer duration of treatment. Alitretinoin has a favorable overall profile of adverse effects; however, female patients who are at risk of becoming pregnant should follow a strict pregnancy-prevention program due to the teratogenic effects of this drug.

Keywords: dermatitis, toctino, CTCL

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