Alitretinoin for the treatment of severe chronic hand eczema
Thomas King, John McKenna, Anton B Alexandroff
Department of Dermatology, University Hospitals of Leicester, Leicester Royal Infirmary, Leicester, UK
Abstract: Chronic hand eczema is a common and often debilitating condition. Alitretinoin, a 9-cis-retinoic acid and pan-retinoic acid agonist, is a new and effective systemic treatment for chronic hand eczema, which provides another treatment option. A “clear” or “almost clear” response can be achieved in up to half of patients within a 24-week course of treatment. Even higher rates of remission can be obtained with a longer duration of treatment. Alitretinoin has a favorable overall profile of adverse effects; however, female patients who are at risk of becoming pregnant should follow a strict pregnancy-prevention program due to the teratogenic effects of this drug.
Keywords: dermatitis, toctino, CTCL
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