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Age-related changes in central corneal thickness in normal eyes among the adult Lithuanian population

Authors Galgauskas S, Juodkaite G, Tutkuviene J

Received 3 February 2014

Accepted for publication 7 April 2014

Published 16 July 2014 Volume 2014:9 Pages 1145—1151

DOI https://doi.org/10.2147/CIA.S61790

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Saulius Galgauskas,1 Grazina Juodkaite,1 Janina Tutkuviene2

1Center of Eye Diseases, 2Faculty of Medicine, Department of Anatomy, Histology and Anthropology, Vilnius University, Vilnius, Lithuania

Background: The purpose of this study was to estimate mean central corneal thickness (CCT) and determine whether there are any correlations between CCT, age, and sex in the adult ­Lithuanian population.
Methods: A total of 1,650 Caucasians of Lithuanian origin (aged 18–89 years) comprising 688 (41.7%) men and 962 (58.3%) women were examined. Subjects were stratified by age into seven groups. CCT was measured using ultrasonic pachymetry. Correlations between CCT, age, and sex were sought.
Results: Mean (± standard deviation) CCT for both eyes was 544.6±30.5 µm. Mean CCT was 545.2±30.5 µm in the left eye and 544.6±30.5 µm in the right eye, and was 545.0±25.6 µm in men and 544.4±33.5 µm in women. Mean CCT was 550.8±35.7 µm in subjects aged 18–29 years, 557.5±27.6 µm in those aged 30–39 years, 551.3±31.4 µm in those aged 50–59 years, 544.0±31.4 µm in those aged 50–59 years, 544.2±31.6 µm in those aged 60–79 years, 535.1±27.8 µm in those aged 70–79 years, and 530.1±16.8 µm in those aged 80–89 years. No statistically significant difference in CCT was found between the sexes (P>0.05). However, there was a significant difference in subjects aged 18–29 years; men had higher CCT than women (P<0.05). A statistically significant negative correlation was found between CCT and age (r=−0.263, P<0.05) that was stronger in men (r=−0.406, P<0.05) than in women (r=−0.118, P<0.05).
Conclusion: The mean CCT in adult Lithuanians was 544.6±30.5 µm, of the left eye 545.2±30.5 µm and of the right – 544.6±30.5 µm. CCT of the right eye was equal to the CCT of both eyes. Mean CCT was 545.0±25.6 µm in men and 544.4±33.5 µm in women. Young men tended to have higher CCT than women. CCT decreases over the lifetime, meaning that older people have thinner corneas. CCT’s dependence on age is stronger in men.

Keywords: central corneal thickness, age, gender, percentile

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