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Advances in the prevention of mother-to-child transmission of HIV and resulting clinical and programmatic implications

Authors Darak S, Parchure R, Darak T, Talavlikar R, Kulkarni S, Kulkarni V

Received 26 February 2014

Accepted for publication 23 April 2014

Published 10 July 2014 Volume 2014:4 Pages 111—123

DOI https://doi.org/10.2147/RRN.S46237

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Shrinivas Darak,1,2 Ritu Parchure,2 Trupti Darak,2 Rachel Talavlikar,3 Sanjeevani Kulkarni,2 Vinay Kulkarni2

1Population Research Centre, Faculty of Spatial Sciences, University of Groningen, the Netherlands; 2PRAYAS Health Group, Pune, India; 3Department of Family Medicine, University of Calgary, Calgary, AB, Canada

Abstract: Following scientific advancements in the prevention of mother-to-child transmission (PMTCT) of HIV, a global plan is being implemented to virtually eliminate new pediatric HIV infections. However, despite revisions to guidelines for providing antiretroviral medications, including the availability of more effective drug regimens over the past decade, and the recent rapid scale-up of PMTCT services, sizeable challenges persist in achieving this goal. This paper provides a summary of recent approaches to the provision of antiretroviral medicines to pregnant women and the resulting implications. Emerging programmatic and service delivery considerations, aiming to increase the effectiveness of PMTCT programs to overcome barriers faced by women in accessing PMTCT services are also discussed. Worldwide elimination of pediatric HIV is now a possibility due to the increasing similarity of PMTCT guidelines in developing countries to those in developed countries. However the resulting practical challenges of implementation will require resources and support at local, national, and international levels. As developing countries strive to adopt and implement more efficacious drug regimens, the effectiveness of PMTCT programs will be determined by coverage of services and the recruitment and retention of pregnant women in the cascade. To expand services and provide an effective, comprehensive approach in under resourced settings, harmonized efforts to address barriers whilst considering contextual factors will be needed.

Keywords: PMTCT, HIV, ARVs, program implementation

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