Menu
Back to Journals » Journal of Pain Research » Volume 6
Advances in cortical modulation of pain
Authors Quintero GC
Received 30 March 2013
Accepted for publication 15 August 2013
Published 19 September 2013 Volume 2013:6 Pages 713—725
DOI https://doi.org/10.2147/JPR.S45958
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 6
Gabriel C Quintero
Florida State University – Panama, Neuroscience, Republic of Panama; Smithsonian Tropical Research Institute (STRI), Balboa, Republic of Panama
Abstract: Pain is an intricate phenomenon composed of not only sensory-discriminative aspects but also of emotional, cognitive, motivational, and affective components. There has been ample evidence for the existence of an extensive cortical network associated with pain processing over the last few decades. This network includes the anterior cingulate cortex, forebrain, insular cortex, ventrolateral orbital cortex, somatosensory cortex, occipital cortex, retrosplenial cortex, motor cortex, and prefrontal cortex. Diverse neurotransmitters participate in the cortical circuits associated with pain processing, including glutamate, gamma-aminobutyric acid, dopamine, and opioids. This work examines recent rodent studies about cortical modulation of pain, mainly at a molecular level.
Keywords: pain, glutamate, glia, cingulate cortex, somatosensory cortex, insular cortex
© 2013 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.
By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.