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Advances in cancer pain from bone metastasis

Authors Zhu X, Zhang J, Ge C, Yu Y, Wang P, Yuan T, Fu C

Received 29 April 2015

Accepted for publication 16 June 2015

Published 18 August 2015 Volume 2015:9 Pages 4239—4245

DOI https://doi.org/10.2147/DDDT.S87568

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr ZhiQiang Yin

Peer reviewer comments 2

Editor who approved publication: Professor Shu-Feng Zhou

Xiao-Cui Zhu,1 Jia-Li Zhang,1 Chen-Tao Ge,1 Yuan-Yang Yu,1 Pan Wang,1 Ti-Fei Yuan,2 Cai-Yun Fu1,3

1College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, 2School of Psychology, Nanjing Normal University, Nanjing, 3Institute for Cell-Based Drug Development of Zhejiang Province, Hangzhou, People’s Republic of China

Abstract: With the technological advances in cancer diagnosis and treatment, the survival rates for patients with cancer are prolonged. The issue of figuring out how to improve the life quality of patients with cancer has become increasingly prominent. Pain, especially bone pain, is the most common symptom in malignancy patients, which seriously affects the life quality of patients with cancer. The research of cancer pain has a breakthrough due to the development of the animal models of cancer pain in recent years, such as the animal models of mouse femur, humerus, calcaneus, and rat tibia. The establishment of several kinds of animal models related to cancer pain provides a new platform in vivo to investigate the molecular mechanisms of cancer pain. In this review, we focus on the advances of cancer pain from bone metastasis, the mechanisms involved in cancer pain, and the drug treatment of cancer pain in the animal models.

Keywords: cancer pain from bone metastasis, animal models of cancer pain, molecular mechanisms, drug treatment

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