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Advanced Black Phosphorus Nanomaterials for Bone Regeneration

Authors Qing Y, Li R, Li S, Li Y, Wang X, Qin Y

Received 16 January 2020

Accepted for publication 9 March 2020

Published 25 March 2020 Volume 2020:15 Pages 2045—2058

DOI https://doi.org/10.2147/IJN.S246336

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Linlin Sun


Yun’an Qing, Ruiyan Li, Shihuai Li, Yuehong Li, Xingyue Wang, Yanguo Qin

Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China

Correspondence: Yanguo Qin
Orthopaedic Medical Center, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, People’s Republic of China
Tel +86-13904315668
Email qinyg@jlu.edu.cn

Abstract: Bone regeneration remains a great clinical challenge. Two-dimensional materials, especially graphene and its derivative graphene oxide, have been widely used for bone regeneration. Since its discovery in 2014, black phosphorus (BP) nanomaterials including BP nanosheets and BP quantum dots have attracted considerable scientific attention and are considered as prospective graphene substitutes. BP nanomaterials exhibit numerous advantages such as excellent optical and mechanical properties, electrical conductivity, excellent biocompatibility, and good biodegradation, all of which make them particularly attractive in biomedicine. In this review, we comprehensively summarize recent advances of BP-based nanomaterials in bone regeneration. The advantages are reviewed, the different synthesis methods of BP are summarized, and the applications to promote bone regeneration are highlighted. Finally, the existing challenges and perspectives of BP in bone regeneration are briefly discussed.

Keywords: 2D materials, black phosphorus nanomaterials, bone regeneration, nanomedicine
 

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