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Administration of supplemental L-tyrosine with phenelzine: a clinical literature review

Authors Hinz M, Stein A, Cole T, Ryan P

Received 6 May 2014

Accepted for publication 20 May 2014

Published 22 July 2014 Volume 2014:6 Pages 107—110

DOI https://doi.org/10.2147/CPAA.S67271

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Marty Hinz,1 Alvin Stein,2 Ted Cole,3 Patricia Ryan4

1Clinical Research, NeuroResearch Clinics, Inc., Cape Coral, FL, USA; 2Stein Orthopedic Associates, Plantation, FL, USA; 3Cole Center for Healing, Cincinnati, OH, USA; 4Family Wellness Center, Omaha, NE, USA

Abstract: The subject of this literature review is the alleged relationship between L-tyrosine, phenelzine, and hypertensive crisis. Phenelzine (Nardil®) prescribing information notes: “The potentiation of sympathomimetic substances and related compounds by MAO inhibitors may result in hypertensive crises (see WARNINGS). Therefore, patients being treated with NARDIL should not take […] L-tyrosine […]”. Interest in the scientific foundation of this claim was generated during routine patient care. A comprehensive literature search of Google Scholar and PubMed revealed no reported cases of hypertensive crisis associated with concomitant administration of L-tyrosine and phenelzine. Review of current US Food and Drug Administration nutritional guidelines relating to ongoing phenelzine studies reveals no mention and requires no consideration of L-tyrosine ingestion in combination with phenelzine. This paper is intended to provide an objective review of the science to then allow the reader to formulate the final opinion.

Keywords: hypertensive crisis, phenelzine, tyrosine, tyramine, stroke, phenelzine

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