Back to Journals » International Journal of Nanomedicine » Volume 8 » Issue 1

Adherence ability of Staphylococcus epidermidis on prosthetic biomaterials: an in vitro study

Authors Shida T, Koseki H, Yoda I, Horiuchi H, Sakoda H, Osaki M

Received 24 July 2013

Accepted for publication 2 September 2013

Published 14 October 2013 Volume 2013:8(1) Pages 3955—3961

DOI https://doi.org/10.2147/IJN.S51994

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Takayuki Shida,1 Hironobu Koseki,1 Itaru Yoda,1 Hidehiko Horiuchi,1 Hideyuki Sakoda,2 Makoto Osaki1

1Department of Orthopedic Surgery, Graduate School of Medicine, Nagasaki University, Nagasaki, Japan; 2Division of Medical Devices, National Institute of Health Sciences, Tokyo, Japan

Abstract: Bacterial adhesion to the surface of biomaterials is an essential step in the pathogenesis of implant-related infections. In this in vitro research, we evaluated the ability of Staphylococcus epidermidis to adhere to the surface of solid biomaterials, including oxidized zirconium-niobium alloy (Oxinium), cobalt-chromium-molybdenum alloy, titanium alloy, commercially pure titanium, and stainless steel, and performed a biomaterial-to-biomaterial comparison. The test specimens were physically analyzed to quantitatively determine the viable adherent density of the S. epidermidis strain RP62A (American Type Culture Collection [ATCC] 35984). Field emission scanning electron microscope and laser microscope examination revealed a featureless, smooth surface in all specimens (average roughness <10 nm). The amounts of S. epidermidis that adhered to the biomaterial were significantly lower for Oxinium and the cobalt-chromium-molybdenum alloy than for commercially pure titanium. These results suggest that Oxinium and cobalt-chromium-molybdenum alloy are less susceptible to bacterial adherence and are less inclined to infection than other materials of a similar degree of smoothness.

Keyword: bacterial adhesion, implant, infection, surface character

Corrigendum for this paper has been published

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

Effect of carbon ion implantation on the tribology of metal-on-metal bearings for artificial joints

Koseki H, Tomita M, Yonekura A, Higuchi T, Sunagawa S, Baba K, Osaki M

International Journal of Nanomedicine 2017, 12:4111-4116

Published Date: 31 May 2017

Adherence ability of Staphylococcus epidermidis on prosthetic biomaterials: an in vitro study [Corrigendum]

Shida T, Koseki H, Yoda I, Horiuchi H, Sakoda H, Osaki M

International Journal of Nanomedicine 2015, 10:5121-5122

Published Date: 12 August 2015

Clinical and histomorphometrical study on titanium dioxide-coated external fixation pins

Koseki H, Asahara T, Shida T, Yoda I, Horiuchi H, Baba K, Osaki M

International Journal of Nanomedicine 2013, 8:593-599

Published Date: 5 February 2013

Readers of this article also read:

Tumor targeting and imaging with dual-peptide conjugated multifunctional liposomal nanoparticles

Rangger C, Helbok A, Sosabowski J, Kremser C, Koehler G, Prassl R, Andreae F, Virgolini IJ, von Guggenberg E, Decristoforo C

International Journal of Nanomedicine 2013, 8:4659-4671

Published Date: 5 December 2013

Immunomagnetic nanoparticle-based assays for detection of biomarkers

Park H, Hwang MP, Lee KH

International Journal of Nanomedicine 2013, 8:4543-4552

Published Date: 22 November 2013

Targeted delivery of let-7a microRNA encapsulated ephrin-A1 conjugated liposomal nanoparticles inhibit tumor growth in lung cancer

Lee HY, Mohammed KA, Kaye F, Sharma P, Moudgil BM, Clapp WL, Nasreen N

International Journal of Nanomedicine 2013, 8:4481-4494

Published Date: 21 November 2013

Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO2 nanotubes: in vivo and in vitro studies

Zhang HZ, Sun Y, Tian A, Xue XX, Wang L, Alquhali A, Bai XZ

International Journal of Nanomedicine 2013, 8:4379-4389

Published Date: 8 November 2013

Synthesis, characterization, and evaluation of paclitaxel loaded in six-arm star-shaped poly(lactic-co-glycolic acid)

Chen Y, Yang Z, Liu C, Wang C, Zhao S, Yang J, Sun H, Zhang Z, Kong D, Song C

International Journal of Nanomedicine 2013, 8:4315-4326

Published Date: 7 November 2013

Antitumor activity of docetaxel-loaded polymeric nanoparticles fabricated by Shirasu porous glass membrane-emulsification technique

Yu YN, Tan SW, Zhao S, Zhuang XT, Song QL, Wang YL, Zhou Q, Zhang ZP

International Journal of Nanomedicine 2013, 8:2641-2652

Published Date: 29 July 2013

Long-term MRI tracking of dual-labeled adipose-derived stem cells homing into mouse carotid artery injury

Qin JB, Li KA, Li XX, Xie QS, Lin JY, Ye KC, Jiang ME, Zhang GX, Lu XW

International Journal of Nanomedicine 2012, 7:5191-5203

Published Date: 2 October 2012