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Add-on administration of ultramicronized palmitoylethanolamide in the treatment of new-onset burning mouth syndrome

Authors Chirchiglia D, Chirchiglia P, Marotta R, Gallelli L

Received 13 November 2018

Accepted for publication 22 January 2019

Published 15 February 2019 Volume 2019:12 Pages 39—42

DOI https://doi.org/10.2147/IMCRJ.S194403

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Professor Ronald Prineas


Domenico Chirchiglia,1 Pasquale Chirchiglia,1 Rosa Marotta,2 Luca Gallelli3

1Department of Neurosurgery, University of Catanzaro, Campus Germaneto, Catanzaro 88100, Italy; 2Department of Medical-Surgical Sciences, University of Catanzaro, Campus Germaneto, Catanzaro 88100, Italy, 3Department of Pharmacology, University of Catanzaro, Campus Germaneto, Catanzaro 88100, Italy

Aim: The purpose of this study was to treat burning mouth syndrome (BMS) with a combination of painful gabapentin and ultramicronized palmitoylethanolamide (umPEA), in an attempt to improve the severe symptomatology of BMS.
Methods: We examined the case of a 60-year-old male, suffering from late-onset burning mouth syndrome. He found that gabapentin had a poor control of symptoms, thus we added umPEA, after administering a Visual Analog Scale (VAS), showing a score of 8–9. The patient also underwent laboratory examinations, neuroimaging exams such as brain CT/MRI and others, which all showed normal results.
Results: The result of combined therapy was satisfactory. After 3 months, the frequency and intensity of the pain had improved considerably, as demonstrated clinically and by VAS, with a score of 5.
Conclusion: BMS is an oral pain-burning syndrome scarcely responsive to therapy. The most widely used medications are GABA-like substances, antidepressants, topiramate. In this case, we used PEA, which proved effective in the treatment of BMS, as well as in neuropathies and migraines.

Keywords: burning mouth syndrome, ultramicronized palmitoylethanolamide, gabapentin


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