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Adaptive optics scanning laser ophthalmoscope imaging: technology update

Authors Merino D, Loza-Alvarez P

Received 2 December 2015

Accepted for publication 15 February 2016

Published 26 April 2016 Volume 2016:10 Pages 743—755

DOI https://doi.org/10.2147/OPTH.S64458

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


David Merino, Pablo Loza-Alvarez

The Institute of Photonic Sciences (ICFO), The Barcelona Institute of Science and Technology, Castelldefels, Barcelona, Spain

Abstract: Adaptive optics (AO) retinal imaging has become very popular in the past few years, especially within the ophthalmic research community. Several different retinal techniques, such as fundus imaging cameras or optical coherence tomography systems, have been coupled with AO in order to produce impressive images showing individual cell mosaics over different layers of the in vivo human retina. The combination of AO with scanning laser ophthalmoscopy has been extensively used to generate impressive images of the human retina with unprecedented resolution, showing individual photoreceptor cells, retinal pigment epithelium cells, as well as microscopic capillary vessels, or the nerve fiber layer. Over the past few years, the technique has evolved to develop several different applications not only in the clinic but also in different animal models, thanks to technological developments in the field. These developments have specific applications to different fields of investigation, which are not limited to the study of retinal diseases but also to the understanding of the retinal function and vision science. This review is an attempt to summarize these developments in an understandable and brief manner in order to guide the reader into the possibilities that AO scanning laser ophthalmoscopy offers, as well as its limitations, which should be taken into account when planning on using it.

Keywords: high-resolution, in vivo retinal imaging, AOSLO

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