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Acute lymphoblastic leukemia in adolescents and young adults – from genomics to the clinics

Authors Kenderian SS, Litzow MR

Received 31 January 2013

Accepted for publication 14 March 2013

Published 29 April 2013 Volume 2013:3 Pages 49—62

DOI https://doi.org/10.2147/COAYA.S29720

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Video abstract presented by Saad Sirop Kenderian

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Saad Sirop Kenderian, Mark R Litzow

Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA

Abstract: Acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYA) represents a unique and challenging disease entity. Despite the recent improvement of survival in this population over the last decade, it is still lagging behind the excellent cure rates obtained in pediatric ALL. This special population of AYA receives care from pediatric as well as adult hematologists and can be treated on pediatric or adult protocols. There is a substantial difference in disease biology, response to chemotherapy, and allogeneic stem cell transplantation between pediatric and AYA patients. This review discusses current controversies in the management of AYA, outcomes following treatment with pediatric and adult protocols, and the role of allogeneic stem cell transplantation. It focuses on the unique clinical, biological, and socioeconomic characteristics of this population that might partly explain the inferior outcomes. This review also explores recent advances in genomic profiling and emerging treatments in ALL.

Keywords: novel agents, monoclonal antibodies, stem cell transplantation, bone marrow transplantation, Philadelphia positive ALL, genomic profile

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