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A review of the application of cellulose hemostatic agent on trauma injuries

Authors Khoshmohabat H, Paydar S, Makarem A, Karami MY, Dastgheib N, Zahraei SAH, Rezaei R, Mahmoudi Nezhad GS

Received 12 February 2019

Accepted for publication 24 July 2019

Published 1 August 2019 Volume 2019:11 Pages 171—177

DOI https://doi.org/10.2147/OAEM.S205006

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Hans-Christoph Pape


Hadi Khoshmohabat,1 Shahram Paydar,2 Alireza Makarem,1,3 Mohammad Yasin Karami,2 Niloofar Dastgheib,4 Seyed Ali Hossein Zahraei,4 Rohallah Rezaei,2 Golnoush Sadat Mahmoudi Nezhad2

1Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; 2Trauma Research Center, Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran; 3Department of Urology, Shiraz University of Medical Sciences, Shiraz, Iran; 4Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

Introduction: Planning for management of bleeding in trauma injuries is very important. The initial purpose in emergency situations should be immediate establishment of an efficient hemostasis, principally in its topical application. In this study, we aimed to review the major relevant articles in the case of application of cellulose hemostatic agent on trauma injuries.
Methods: We searched the online databases such as PubMed, MEDLINE, Wiley, EMBASE, ISI Web of Knowledge, and Scopus. Two reviewers independently searched and assessed the titles and abstracts of all articles.
Results: Upon screening the titles and abstracts, 24 studies were identified for full-text review. The oxidized cellulose had the best clotting times, while it demonstrated low absorption ability. Surgical and thermosensitive chitosan hemostatic could be valuable for managing hemorrhage from liver injuries in trauma patients.
Conclusion: Recently, the application of cellulose hemostatic agents has been one of the main improvements obtained for controlling bleeding in trauma injuries. However, generally according to the literature review, the decision about using each agent should be made on a case-by-case basis. However, it can be mentioned that the perfect hemostatic agent has not been still identified.

Keywords: cellulose hemostatic agent, trauma, injury


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