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A Qualitative Study of Barriers and Facilitators to Adherence to Secondary Prevention Medications Among French Patients Suffering from Stroke and Transient Ischemic Attack

Authors Viprey M, Gouillet M, Puppo C, Termoz A, Della Vecchia C, Derex L, Haesebaert J, Schott AM, Préau M

Received 8 April 2020

Accepted for publication 23 June 2020

Published 21 July 2020 Volume 2020:14 Pages 1213—1223


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Johnny Chen

Marie Viprey,1,2 Maïlys Gouillet,3 Costanza Puppo,3 Anne Termoz,1,2 Claire Della Vecchia,2,3 Laurent Derex,2,4 Julie Haesebaert,1,2 Anne-Marie Schott,1,2 Marie Préau3

1Public Health Department, Hospices Civils de Lyon, Lyon, France; 2HESPER EA 7425, University of Lyon, University Claude Bernard Lyon 1, Lyon, France; 3GRePS, Lyon 2 University, Lyon, France; 4Comprehensive Stroke Center, Pierre Wertheimer Hospital, Hospices Civils de Lyon, Bron, France

Correspondence: Marie Viprey
Hospices Civils de Lyon, Pôle de Santé Publique, Bâtiment A, 6ème étage, 162, Avenue Lacassagne, Lyon 69003, France
Tel +33 4 72 11 53 02

Purpose: Secondary prevention medications (SPM) reduce the risk of ischemic stroke (IS) and transient ischemic attack (TIA) recurrence. However, approximately one-third of patients are estimated to be non-adherent. This qualitative study aimed to explore barriers and facilitators to adherence to SPM after IS or TIA.
Patients and Methods: Thirty-six face-to-face semi-structured interviews were conducted with 14 TIA patients and 22 IS patients who self-administered their treatment 12 months after IS/TIA. A thematic analysis was performed.
Results: Major facilitators to good adherence to SPM were the fear of stroke recurrence and the high level of trust in the prescribing physician. Barriers included a perceived lack and/or inappropriate timing of information about SPM, practical difficulties of taking some SPM (eg, inadequate packaging) and of implementing routines into their daily life.
Conclusion: Information on SPM is inadequate in terms of quantity and timing both during the acute IS/TIA period and over the long term. Providing more tailor-made information at an opportune moment, in particular by promoting discussion with their general practitioner (GP) throughout the course of illness and recovery, is essential to ensure that patients are not left alone in the decision-making process regarding adherence to SPM.

Keywords: medication adherence, stroke, transient ischemic attack, qualitative study

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