A novel curcumin-loaded composite dressing facilitates wound healing due to its natural antioxidant effect
Received 12 June 2019
Accepted for publication 7 August 2019
Published 16 September 2019 Volume 2019:13 Pages 3269—3280
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Dr Anastasios Lymperopoulos
Yong Zhao,1 Chuanyu Dai,2 Zheng Wang,1 Weimin Chen,1 Jiaguo Liu,3 Renxi Zhuo,2 Aixi Yu,1 Shiwen Huang2
1Department of Orthopedic Trauma and Microsurgy, Zhongnan Hospital of Wuhan University, Wuhan 430070, Hubei, People’s Republic of China; 2Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, Hubei 430072, People’s Republic of China; 3Department of Orthopedics, Hubei University of Medicine Affliated Taihe Hospital, Shiyan 442000, Hubei, People’s Republic of China
Correspondence: Aixi Yu
Department of Orthopedic Trauma and Microsurgy, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuchang District, Wuhan 430070, Hubei, People’s Republic of China
Tel +86 1 350 718 7489
Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, 16 Luojiashan Road, Wuchang District, Wuhan 430072, Hubei, People’s Republic of China
Tel +86 186 2786 5822
Purpose: To prepare a novel wound dressing to facilitate cutaneous wound healing.
Methods: Curcumin (Cur) was added to the ring-shaped β-cyclodextrin (CD) to form a β-CD–Cur inclusion complex (CD-Cur). CD-Cur was then integrated into a composite chitosan–alginate (CA) mix. Finally, CA-CD-Cur was generated with a freeze-drying technique. Water-uptake capacity, degradation rate, and drug-release kinetics of the newly formed dressing were investigated in vitro. In animal studies, cutaneous wounds in rats were created, treated with CA-CD-Cur, then compared to CA-Cur, CA, and gauze.
Results: CA-CD-Cur–treated wounds showed accelerated closure rates, improved histopathological results, and lower SOD, lipid peroxidation, pI3K, and pAktkt levels than other groups. On the contrary, catalase, IκBα, and TGFβ1 levels were higher than others.
Conclusion: CA-CD-Cur may facilitate cutaneous wound dressing that facilitate wound healing.
Keywords: curcumin, cyclodextrin inclusion complex, chitosan, alginate, cutaneous wound healing
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