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A narrative review of psoriasis and multiple sclerosis: links and risks

Authors Silfvast-Kaiser AS, Homan KB, Mansouri B

Received 4 May 2019

Accepted for publication 6 August 2019

Published 22 August 2019 Volume 2019:9 Pages 81—90

DOI https://doi.org/10.2147/PTT.S186637

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 2

Editor who approved publication: Professor Uwe Wollina


Annika S Silfvast-Kaiser,1 Katie B Homan,2 Bobbak Mansouri3–5

1Department of Dermatology, Baylor Scott and White, Dallas, TX, USA; 2Department of Dermatology, Baylor Scott and White Medical Center, Temple, TX, USA; 3Austin Institute for Clinical Research, Pflugerville, TX, USA; 4Sanova Dermatology – Pflugerville, Pflugerville, TX, USA; 5U.S. Dermatology Partners - Tyler, TX, USA

Correspondence: Bobbak Mansouri
US Dermatology Partners - Tyler, TX 1367 Dominion Plaza, Pflugerville, TX 75703, USA
Email bobbak.mansouri@gmail.com

Abstract: The association of psoriasis (PsO) with other autoimmune and autoinflammatory diseases has long been a topic of interest. Although previous studies have attempted to clarify the specific relationship between PsO and multiple sclerosis (MS), it remains obscure, with limited and conflicting evidence regarding a link between the two entities. Herein, we review the etiology, pathogenesis, and treatment of each disease and present the available literature to-date regarding a possible relationship between PsO and MS. We conclude that further study is necessary to discern whether there may be a significant relationship between PsO and MS. In the meantime, clinicians may find it appropriate to screen for MS in patients with PsO, allowing for timely referral to a neurologist should it be necessary.

Keywords: psoriasis, multiple sclerosis, incidence, prevalence, links, risk factors

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