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A comparison of the genetic and clinical profile of men that respond and do not respond to the immediate antihypertensive effects of aerobic exercise

Authors Pescatello LS, Blanchard BE, Tsongalis GJ, O'Connell AA, Gordish-Dressman H, Maresh CM, Thompson PD

Published 18 September 2008 Volume 2008:1 Pages 7—17


Review by Single anonymous peer review

Peer reviewer comments 2

Linda S Pescatello1, Bruce E Blanchard2, Gregory J Tsongalis3, Ann A O’Connell4, Heather Gordish-Dressman5, Carl M Maresh1, Paul D Thompson6

1Department of Kinesiology, University of Connecticut, Storrs, CT, USA; 2Department of Pathology; 3Department of Pathology, Dartmouth Medical School and Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA; 4School of Educational Policy and Leadership, Ohio State University, Columbus, OH, USA; 5Research Center for Genetic Medicine, Children’s National Medical Center, Washington, DC, USA; 6Division of Cardiology, Hartford Hospital, Hartford, CT, USA

Abstract: We compared the genetic and clinical profile of men who lower and do not lower blood pressure (BP) after acute aerobic exercise. Volunteers were 45 men (Mean ± SEM, 43.5 ± 1.5 yr) with high BP (145.7 ± 1.5/85.7 ± 1.1 mmHg). They completed three experiments: nonexercise control and two cycle exercise sessions at 40% and 60% peak oxygen consumption, and were then instrumented to an ambulatory BP monitor. Logistic regression determined the genetic and clinical profile of men who lowered BP after exercise (responders [ExR n = 36]); and those who did not (nonresponders [ExNR n = 9]). ExR had higher C-reactive protein (CRP), high-density lipoprotein (HDL), the metabolic syndrome, family history of hypertension, more renin-angiotensin system (RAS) common alleles, and α-adducin Trp460 and endothelial nitric oxide synthase (ENOS) C786 risk alleles. ExNR had lower CRP and HDL, did not have the metabolic syndrome and a family history of hypertension, had more RAS risk alleles, and had the α-adducin Gly460Gly and ENOS T786T genotypes. This model had a sensitivity of 97.1%, specificity of 75.0%, and accounted for 46.3%–74.4% of the BP response. These results suggest genetic and clinical information may eventually be used to characterize people who do and do not respond to exercise as antihypertensive therapy.

Keywords: blood pressure, genetics, hypertension, metabolic syndrome, physical activity

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