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A Comparative Study on Adipose-Derived Mesenchymal Stem Cells Secretome Delivery Using Microneedling and Fractional CO2 Laser for Facial Skin Rejuvenation [Letter]
Authors Rinendyaputri R
Received 14 February 2023
Accepted for publication 25 February 2023
Published 9 March 2023 Volume 2023:16 Pages 613—614
DOI https://doi.org/10.2147/CCID.S408555
Checked for plagiarism Yes
Editor who approved publication: Dr Jeffrey Weinberg
Ratih Rinendyaputri
Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency, Cibinong, West Java, Indonesia
Correspondence: Ratih Rinendyaputri, Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency, Cibinong, West Java, Indonesia, Email [email protected]
View the original paper by Dr Yusharyahya and colleagues
A Response to Letter has been published for this article.
Dear editor
Mesenchymal stem cell/MSC secretome are used in dermatology to treat skin problems such as wound healing, alopecia, psoriasis, antimicrobial, and photoprotection.1 Secretome can be used to treat skin rejuvenation as well as degenerative diseases. The research was carried out by Yusharyahya et al, which performed insightful novelty in the administration secretome for skin rejuvenation.2 However, some insights were discussed and suggestions for future research in this field were made.
The route of administration of the secretome is critical to the treatment’s success. Secretome has been administered topically and subcutaneously and has been shown to increase skin regeneration, blood vessel formation, and be anti-inflammatory in the skin lesions.3,4 Yusharyahya et al recently reported that secretome administration for skin rejuvenation using microneedling (MN) and fractional CO2 laser (FL) could significantly improve total dermoscopy photoaging scale (DPAS and Janus-III measurement system.2
Previous research has shown that secretome derived from bone marrow-derived mesenchymal stem cells/BMMSCs can protect dermal fibroblasts from oxidative stress and UVB.5 Balasubramanian et al use base array antibodies to analyze cytokines, growth factors, and chemokines in treatment secretions.5 Knowing the protein level and profile in the secretome can be used as a reference for further research in determining the dose of the secretome.
This study only reports on the proteins studied and excludes protein levels in the secretome. This is a clinical trial designed to demonstrate the safety and efficacy of secretome therapy in skin rejuvenation in a dose-dependent manner. The protein concentrations examined in this publication, in our opinion, are important in paying doses. Similarly, the characterization of adipose derived mesenchymal stem cells/ADMSC, which is not covered in this article, is lacking. Future research will focus on dosage and source characterization.
Acknowledgments
Yusharyahya S et al should be commended for their fruitful collaboration in this field. Furthermore, authors would like to thank Dr. Sunarno and all researchers at the Center for Biomedical Research BRIN for their ongoing support.
Author Contributions
RR wrote the original version of manuscript and revised the letter manuscript accordingly.
Disclosure
The author stated that there is no conflict of interest regarding this communication.
References
1. Damayanti RH, Rusdiana T, Wathoni N. Mesenchymal stem cell secretome for dermatology application: a review. In: Clinical, Cosmetic and Investigational Dermatology. Vol. 14. Dove Medical Press Ltd; 2021:1401–1412.
2. Yusharyahya SN, Japranata VV, Sitohang IBS, et al. A comparative study on adipose-derived mesenchymal stem cells secretome delivery using microneedling and fractional CO2 laser for facial skin rejuvenation. Clin Cosmet Investig Dermatol. 2023;16:387–395. doi:10.2147/CCID.S401839
3. Yang M, Wang L, Chen Z, et al. Topical administration of the secretome derived from human amniotic epithelial cells ameliorates psoriasis-like skin lesions in mice. Stem Cell Res Ther. 2022;13(1). doi:10.1186/s13287-022-03091-9
4. Silveira BM, Ribeiro TO, Freitas RS, et al. Secretome from human adipose-derived mesenchymal stem cells promotes blood vessel formation and pericyte coverage in experimental skin repair. PLoS One. 2022;17(12):e0277863. doi:10.1371/journal.pone.0277863
5. Balasubramanian S, Thej C, Walvekar A, et al. Evaluation of the secretome profile and functional characteristics of human bone marrow mesenchymal stromal cells-derived conditioned medium suggest potential for skin rejuvenation. J Cosmet Dermatol Sci Appl. 2017;7(1):99–117. doi:10.4236/jcdsa.2017.71010
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