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A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy

Authors Wang H, Zhang Y, Zeng X, Pei W, Fan R, Wang Y, Wang X, Li J

Received 29 December 2020

Accepted for publication 7 March 2021

Published 23 March 2021 Volume 2021:16 Pages 2373—2388


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Farooq A. Shiekh

Hairong Wang, Yawen Zhang, Xiangle Zeng, Wenjun Pei, Ranran Fan, Yushuai Wang, Xiu Wang, Jianchun Li

School of Pharmacy, Bengbu Medical College, Bengbu, 233030, People’s Republic of China

Correspondence: Jianchun Li
School of Pharmacy, Bengbu Medical College, Bengbu, 233030, People’s Republic of China
Tel +86 552-3175066
Email [email protected]

Aim: The metastasis of breast cancer is an important cause of tumor recurrence. This study highlights that tyrosine kinase inhibitors dasatinib (DAS) and rosiglitazone (ROZ) inhibit tumor growth and reduce the occurrence of tumor cell metastasis. Due to the poor water solubility, short half-time in the body of DAS and ROZ, which increases the difficulty of tumor treatment, as well as the demand for nano-drug delivery systems for organ-specific therapies.
Methods: Hyaluronic acid (HA) and DAS are bonded by a pH-sensitive ester bond to form an HA-DAS polymer. Then, ROZ was added as the core, D-A-tocopherol polydiethylene glycol isosuccinate (TPGS) and HA-DAS were used as carriers to form HA-DAS and TPGS mixed micelle system loaded with ROZ (THDR-NPs). The size and structure of THDR-NPs were characterized, the drug release, stability and biosafety of THDR-NPs were studied. In vitro, the cytotoxicity, targeting effect and tumor metastasis inhibition of THDR-NPs were evaluated in human breast cancer cell lines. In addition, the selective potency of designed THDR-NPs in depleting was further verified in vivo in the tumor-bearing nude mice model.
Results: The designed THDR-NPs have a particle size of less than 100 nm, good stability, biological safety and sustained release, and showed strong therapeutic effects on breast cancer models in vitro and in vivo. Moreover, it has been proved that THDR-NPs have the ability to inhibit tumor metastasis.
Conclusion: DAS and ROZ were designed into micelles, the efficacy of THDR-NPs was higher than that of free drugs. These results indicate that nanoparticles have a good application prospect in the treatment of tumor metastasis.

Keywords: HA targeting, inhibiting metastasis, polymer, micelle

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