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A case report of Epstein–Barr virus-associated retinal vasculitis: successful treatment using only acyclovir therapy

Authors Keorochana N

Received 24 February 2016

Accepted for publication 31 March 2016

Published 25 July 2016 Volume 2016:9 Pages 213—218

DOI https://doi.org/10.2147/IMCRJ.S107089

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Narumon Keorochana

Department of Ophthalmology, Phramongkutklao Hospital, Bangkok, Thailand

Abstract: The purpose of this study was to describe a presumed case of Epstein–Barr virus (EBV)-associated retinal vasculitis in a 42-year-old female with sudden unilateral vision loss and successful treatment with acyclovir therapy. Diagnostic vitreous biopsy of the right eye was performed to test for EBV and other known infectious causes of retinitis and evaluate vitreous cells and serological testing. Vitreous polymerase chain reaction viral DNA testing result was positive for EBV but negative for herpes simplex virus, varicella-zoster virus, and cytomegalovirus. Serologic testing was negative for toxoplasma gondii, syphilis, tuberculosis, and HIV. Histopathologic analysis of vitreous cells revealed atypical lymphocytes. Fluorescein angiography showed disk leakage, occluded retinal artery, peripheral vascular leakage, and ischemic area of the right eye. Intravenous acyclovir, 10 mg/kg/d, was prescribed for 14 days followed by oral acyclovir for 3 months. All lesions have become quiet. EBV may be a cause of retinal disease, and intravenous acyclovir is a successful treatment choice.

Keywords: Epstein-Barr virus, retinal vasculitis, acyclovir, treatment

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