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A 10-year retrospective study of alterative aeroallergens sensitization spectrum in urban children with allergic rhinitis

Authors Yang LF, Cai LM, Li M, Liu JT, Wang ZN, Wang WH, Yang QT, Chen ZG

Received 20 October 2017

Accepted for publication 15 January 2018

Published 26 February 2018 Volume 2018:14 Pages 409—416

DOI https://doi.org/10.2147/TCRM.S154692

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Hoa Le

Peer reviewer comments 2

Editor who approved publication: Professor Deyun Wang


Li-Fen Yang,1,* Liang-Ming Cai,1,* Ming Li,2,* Jin-Tao Liu,3 Zhao-Ni Wang,1 Wei-Hao Wang,4 Qin-tai Yang,4 Zhuang-Gui Chen1,5

1Department of Pediatrics Intensive Care Unit and Respiratory Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Department of Pulmonary Diseases, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China; 3Department of Population and Quantitative Health Science, Case Western Reserve University, Cleveland, OH, USA; 4Department of Otorhinolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China; 5Institution of Respiratory Diseases of Sun Yat-sen University, Guangzhou, People’s Republic of China

*These authors contributed equally to this work

Objective: To investigate the alterative spectrum and trends of aeroallergens sensitization in children with allergic rhinitis (AR) in Guangzhou, China in the past 10 years.
Participants and methods: In this retrospective study, 4,111 children with complaints of nasal hyper-reactivity who visited the Pediatric Department and/or Otolaryngology Department from January 2007 to November 2016 were enrolled. Serum specific immunoglobulin E was measured and positive detection was made in 3,328 patients, who were, therefore, diagnosed with AR. Positive rates and trends of different aeroallergens sensitization were assessed. The tendency of positive rates changing over the years, and the difference and trends in positive rate of aeroallergen sensitization that occurred in subgroups of gender, age, and season were determined and analyzed with logistic regression.
Results: The percentage of detected common aeroallergens in AR children was (from high to low) 81.07%, 34.44%, 14.72%, 11.81%, 6.04%, and 3.70% for house dust mites (HDMs), cat–dog dander, cockroach, mold mixture, tree pollen mixture, and herb pollen mixture, respectively. An ascending trend of aeroallergens sensitization or AR (odds ratio [OR] =1.116, 95% CI: 1.086–1.146) was found. Interestingly, an increasing trend of cat–dog dander and mold sensitization was found in AR children (OR =1.164, 95% CI: 1.133–1.196; OR =1.169, 95% CI: 1.120–1.223) in this retrospective study, while HDMs sensitization held a steady trend (OR =0.983, 95% CI: 0.961–1.007).
Conclusion: In the increasing trend of aeroallergens sensitization or AR, HDMs sensitization still held the majority. But emphasis should be made on pet allergy for young children with AR in the context of ascending trend of sensitization to cat–dog dander.

Keywords: allergic rhinitis, aeroallergen, children, sIgE

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