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5-HTP efficacy and contraindications

Authors Hinz M, Stein A, Uncini T

Received 24 April 2012

Accepted for publication 14 May 2012

Published 19 July 2012 Volume 2012:8 Pages 323—328


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

This paper has been retracted.

Marty Hinz, 1 Alvin Stein, 2 Thomas Uncini 3

Clinical Research, NeuroResearch Clinics, Inc, Cape Coral, 2Stein Orthopedic Associates, Plantation, FL, USA; 3University Medical Center Mesabi Hibbing, MN, USA

Abstract: L-5-hydroxytryptophan (5-HTP) is the immediate precursor of serotonin. It is readily synthesized into serotonin without biochemical feedback. This nutrient has a large and strong following who advocate exaggerated and inaccurate claims relating to its effectiveness in the treatment of depression and a number of other serotonin-related diseases. These assertions are not supported by the science. Under close examination, 5-HTP may be contraindicated for depression in some of the very patients for whom promoters of 5-HTP advocate its use.

Keywords: 5-HTP, 5-hydroxytryptophan, L-5-HTP, L-5-hydroxytryptophan

Expression of Concern for this paper has been published

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