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18F-fluorodeoxyglucose positron emission tomography might be useful for diagnosis of hepatic amyloidosis

Authors Tawada A, Kanda T, Oide T, Tsuyuguchi T, Imazeki F, Nakatani Y, Yokosuka O

Received 1 March 2014

Accepted for publication 3 May 2014

Published 20 June 2014 Volume 2014:7 Pages 103—109

DOI https://doi.org/10.2147/IMCRJ.S63296

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Akinobu Tawada,1 Tatsuo Kanda,1 Takashi Oide,2 Toshio Tsuyuguchi,1 Fumio Imazeki,1,3 Yukio Nakatani,2 Osamu Yokosuka1

1Department of Gastroenterology, 2Department of Diagnostic Pathology, Chiba University Hospital, Chuo-ku, Chiba, Japan; 3Safety and Health Organization, Chiba University, Inage-ku, Chiba, Japan

Abstract: We report on a woman with hepatic involvement of primary systemic (immunoglobulin light chain, AL) amyloidosis. Her diagnosis was confirmed by liver biopsy. Clinical symptoms of hepatic amyloidosis are generally mild at its first stage, with most frequent findings being hepatomegaly and alkaline phosphatase elevation. Recent advances in the understanding of the pathophysiology of systemic amyloidosis have made several treatments available. However, its prognosis is occasionally poor. Because liver biopsy is not always safe, other modalities for the diagnosis are needed. Of interest was that fluorodeoxyglucose (FDG) uptake into the liver was observed, compared with that into the spleen, in this patient, indicating that FDG positron emission tomography and computed tomography might be useful for the diagnosis of hepatic amyloidosis with mild liver dysfunction.

Keywords: amyloidosis, diagnosis, hepatic involvement, FDG PET

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