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Young patients with risk factors prevalent in the elderly – 
differences in comorbidity depending on severity of psoriasis: a nationwide cross-sectional study in Swedish health registers

Authors Hajiebrahimi M, Linder M, Hägg D, Anveden Berglind I, McElligott S, Valgardsson VS, Villacorta R, Sundström A

Received 8 February 2018

Accepted for publication 20 March 2018

Published 19 June 2018 Volume 2018:10 Pages 705—715

DOI https://doi.org/10.2147/CLEP.S164918

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Professor Henrik Toft Sørensen


Mohammadhossein Hajiebrahimi,1,2 Marie Linder,1 David Hägg,1 Ina Anveden Berglind,1 Sean McElligott,3 Valgard Sverrir Valgardsson,4 Reginald Villacorta,3 Anders Sundström1

1Center for Pharmacoepidemiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden; 2Statistics and Epidemiology Unit, Health Faculty, Golestan University of Medical Sciences, Gorgan, Iran; 3Janssen Research and Development, LLC, Horsham, PA, USA; 4Janssen-Cilag AS, Oslo, Norway

Background: Association between psoriasis severity and cerebro- and cardiovascular comorbidities has rarely been investigated.
Aim: We aimed to investigate differences in cerebro- and cardiovascular comorbidities by psoriasis severity.
Materials and methods: Using Swedish nationwide health-care registers, new adult users of anti-psoriatic drugs (2007–2013) with a recorded diagnosis of psoriasis/psoriatic arthritis or a filled prescription for calcipotriol were included. Psoriasis severity was based on the type of anti-psoriatic treatment (topical/mild, non-biologic systemic/moderate-to-severe, and biologics/severe). Age standardized prevalence rates of cerebro- and cardiovascular comorbidities and their risk factors were compared between the groups.
Results: We found that severe psoriasis patients (N=2147) were younger than moderate-to-severe (N=11,919) or mild (N=70,796) patients (median 44, 52, and 55 years). Prevalence of hypertension was 29.9%, 32.6%, and 36.5%, myocardial infarction was 2.5%, 2.3%, and 1.8%, and stroke was 2.4%, 2.2%, and 1.1% in mild, moderate-to-severe, and severe psoriasis patients, respectively. Diabetes prevalence was 7.6% in mild, 8.0% in moderate-to-severe, and 10.7% in severe psoriasis.
Conclusion: Myocardial infarction and stroke were less common in patients with severe psoriasis while, despite being younger, they had a higher prevalence of diabetes and hypertension.

Keywords: psoriasis, severity, cardiovascular, cerebrovascular, prevalence

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