Back to Journals » Neuropsychiatric Disease and Treatment » Volume 14

Von Economo’s disease and postencephalitic parkinsonism responsive to carbidopa and levodopa

Authors Bigman DY, Bobrin BD

Received 5 October 2017

Accepted for publication 27 November 2017

Published 4 April 2018 Volume 2018:14 Pages 927—931


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder

Daniel Y Bigman, Bradford D Bobrin

Department of Psychiatry, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, USA

Abstract: Postencephalitic parkinsonism (PEP) is currently perceived as having a very close etiologic relationship with encephalitis lethargica (von Economo’s disease [EL]), with PEP developing immediately after the acute phase of EL or at some time later. EL was classically described by von Economo and has somnolent-ophthalmoplegic, hyperkinetic, and amyostatic-akinetic forms. Previous cases have reported success with levodopa in PEP. We report a case with PEP showing success after administration of levodopa and carbidopa. This case would support the hypothesis that this syndrome effects dopamine neurotransmission.

Keywords: von Economo, encephalitis lethargica, postencephalitic parkinsonism, carbidopa, levodopa, catatonia

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]