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Vitreous Reflux Frequency and Intraocular Pressure After First-Time Intravitreal Aflibercept Injections: Comparison of 30- and 32-Gauge Needles

Authors Muto T, Machida S

Received 22 December 2019

Accepted for publication 19 February 2020

Published 3 March 2020 Volume 2020:14 Pages 625—634


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Tetsuya Muto, Shigeki Machida

Department of Ophthalmology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan

Correspondence: Tetsuya Muto
Department of Ophthalmology, Dokkyo Medical UniversitySaitama Medical Center, 2-1-50 Minamikoshiagya, Koshigaya 343-8555, Japan
Tel +81 48 965 1111
Fax +81 48 965 1127

Purpose: To compare the effects of 30-gauge versus 32-gauge needles on vitreous reflux (VR) frequency and intraocular pressure (IOP) following first-time intravitreal aflibercept injections.
Materials and Methods: Overall, 116 patients (116 eyes) who received intravitreal injections using 30-gauge needles and 104 patients (104 eyes) who received the same injection using 32-gauge needles were reviewed. The medical records of 116 patients who each received an intravitreal injection using a 30-gauge needle (median age: 67.5 ± 13.9 years) and 104 patients who each received the same injection using a 32-gauge needle (median age: 66. 3 ± 10.6 years) from January 2015 to June 2019 were compared.
Results: No significant difference in the frequency of VR was observed between patients injected using 30-gauge needles (38/116) and patients injected using 32-gauge needles (31/104, P = 0.64). There were no significant differences in the VR rates of patients with phakic and pseudophakic eyes between those injected using 30-gauge (P = 0.94) or 32-gauge needles (P = 0.77). Axial length did not significantly differ between patients with and without VR when injected using 30-gauge (P = 0.89) and with 32-gauge needles (P = 0.69). IOP immediately after injection was significantly higher in patients injected using 30-gauge needles than in patients injected using 32-gauge needles (P < 0.01).
Conclusion: VR frequency was not correlated with needle size, lens status, or axial length. Patients receiving injections using 30-gauge needles had higher IOP immediately after intravitreal injection.

Keywords: aflibercept, intravitreal injection, vitreous reflux, intraocular pressure

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