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Vitellaria paradoxa Nut Triterpene-Rich Extract Ameliorates Symptoms of Inflammation on Post-Traumatic Osteoarthritis in Obese Rats

Authors Sudirman S, Chen CK, Long BT, Chang HW, Tsou D, Kong ZL

Received 26 August 2019

Accepted for publication 10 December 2019

Published 30 January 2020 Volume 2020:13 Pages 261—271

DOI https://doi.org/10.2147/JPR.S228766

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr E Alfonso Romero-Sandoval


Sabri Sudirman, Chun-Kai Chen, Bing-Ting Long, Heng-Wei Chang, David Tsou, Zwe-Ling Kong

Department of Food Science, National Taiwan Ocean University, Keelung City 20224, Taiwan

Correspondence: Zwe-Ling Kong
Department of Food Science, National Taiwan Ocean University, Keelung City 20224, Taiwan
Tel/Fax +886 2 24622192 Ext. 5130
Email kongzl@mail.ntou.edu.tw

Purpose: To investigate the ameliorative effects of Vitellaria paradoxa (VP) nut extract for an anterior cruciate ligament transection with medial meniscectomy (ACLT+MMx)-induced osteoarthritis (OA) in high-fat diet (HFD)-induced obese rats.
Methods: The rats were fed by HFD for 5 weeks before surgery-induced OA. Rats were treated orally with three different doses of VP nut extract (111.6, 223.2, and 446.4 mg/kg) for 8 weeks.
Results: The VP nut triterpene-rich extract decreased the level of triglycerides and increased high-density lipoprotein-cholesterol. The level of nitric oxide, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α decreased after treatment with VP nut triterpene-rich extract, especially in high-doses. The VP nut triterpene-rich extracts also alleviated swelling in the knee OA, weight-bearing difference, and suppressed cartilage degradation.
Conclusion: The Vitellaria paradoxa nut triterpene-rich extract suppressed proinflammatory mediators and attenuated the cartilage degradation and pain in osteoarthritis with an obesity rat model. As such, Vitellaria paradoxa nut triterpene-rich extract can be used as an alternative for osteoarthritis treatment.

Keywords: medial meniscectomy, obesity, osteoarthritis, triterpene, Vitellaria paradoxa

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