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Virus–Receptor Interactions: Structural Insights For Oncolytic Virus Development

Authors Jayawardena N, Burga LN, Poirier JT, Bostina M

Received 6 June 2019

Accepted for publication 2 October 2019

Published 29 October 2019 Volume 2019:8 Pages 39—56

DOI https://doi.org/10.2147/OV.S218494

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Chae-Ok Yun


Nadishka Jayawardena,1 Laura N Burga,1 John T Poirier,2 Mihnea Bostina1,3

1Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand; 2Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA; 3Otago Micro and Nano Imaging, University of Otago, Dunedin, New Zealand

Correspondence: Mihnea Bostina
Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
Tel +64 22 44 5583 Email mihnea.bostina@otago.ac.nz

Abstract: Recent advancements in oncolytic virotherapy commend a special attention to developing new strategies for targeting cancer cells with oncolytic viruses (OVs). Modifications of the viral envelope or coat proteins serve as a logical mean of repurposing viruses for cancer treatment. In this review, we discuss how detailed structural knowledge of the interactions between OVs and their natural receptors provide valuable insights into tumor specificity of some viruses and re-targeting of alternate receptors for broad tumor tropism or improved tumor selectivity.

Keywords: oncolytic viruses, virus–receptor interaction, virus entry

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