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Vaginal rings for delivery of HIV microbicides

Authors Malcolm K, Fetherston, McCoy, Boyd, Major

Received 31 August 2012

Accepted for publication 16 October 2012

Published 20 November 2012 Volume 2012:4 Pages 595—605


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

R Karl Malcolm, Susan M Fetherston, Clare F McCoy, Peter Boyd, Ian Major

School of Pharmacy, Queen's University Belfast, Belfast, UK

Abstract: Following the successful development of long-acting steroid-releasing vaginal ring devices for the treatment of menopausal symptoms and contraception, there is now considerable interest in applying similar devices to the controlled release of microbicides against HIV. In this review article, the vaginal ring concept is first considered within the wider context of the early advances in controlled-release technology, before describing the various types of ring device available today. The remainder of the article highlights the key developments in HIV microbicide-releasing vaginal rings, with a particular focus on the dapivirine ring that is presently in late-stage clinical testing.

Keywords: controlled release, sustained release, antiretroviral, dapivirine, SILCS diaphragm, silicone elastomer, thermoplastic

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