Back to Journals » Advances in Genomics and Genetics » Volume 3

Type 2 diabetes in a central Indian population: association with PPARG2 P121A allele but not ENPP1 K121Q

Authors Tripathi AK, Shukla S, Dwivedi M, Tripathi JK, Chauhan U, Indurkar M, Singh S

Received 18 January 2013

Accepted for publication 27 February 2013

Published 4 April 2013 Volume 2013:3 Pages 1—9


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Arvind Kumar Tripathi,1 Smriti Shukla,1 Mrigendra Kumar Dwivedi,1 Jitendra Kumar Tripathi,1 Ugam Kumari Chauhan,1 Manoj Indurkar,2 Shivam Singh1

1Centre for Biotechnology Studies, Awdhesh Pratap Singh University, 2Department of Medicine, Shyam Shah Medical College, Rewa, India

Background: It is known that genetic and environmental factors may influence susceptibility to type 2 diabetes and its complications.
Objective: In the investigation reported here we selected the peroxisome proliferator-activated receptor (PPAR) G2 (rs1801282) and ENPP1, also called PC-1 (rs1044498) gene polymorphisms to determine whether there is a genetic association between these, obesity, and type 2 diabetes. We also examined and environmental factors influencing type 2 diabetes.
Design and methods: The study was carried out on a central Indian population of 190 diabetics and 210 healthy controls. Anthropometric data were collected during sample collection. A genetic polymorphism study of PPARG2 and ENPP1 was undertaken using a polymerase chain reaction restriction fragment length polymorphism method and the observed genotype frequencies, allele frequencies, and carriage rates of the PPARG2 and ENPP1 polymorphisms were recorded.
Results: The patterns of genotype and allele distribution in both groups suggested a significant association between PPARG2 Pro12Ala major allele A carriage (AA carriage) and type 2 diabetes. Further, the results also show the protective effect of the minor allele G. Overall, we found that the distribution of ENPP1 K121Q genotypes was not significantly different between healthy controls and diabetic patients. Thus, ENPP1 polymorphism was not found to be associated with type 2 diabetes in a central Indian population. Body mass index was also found to be significantly higher in female diabetic patient group than in female healthy controls (P = 0.0388), while there was no significant difference in body mass index for males in the case group compared with in the control group.
Conclusion: Our study indicates that PPARG2 and obesity have a strong association with type 2 diabetes but ENPP1 polymorphism lacks any association.

Keywords: obesity, BMI, polymorphism, restriction fragment length polymorphism, peroxisome proliferator-activated receptors

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 


Readers of this article also read:

Adipose tissue-secreted miR-27a promotes liver cancer by targeting FOXO1 in obese individuals

Sun B, Li J, Shao D, Pan Y, Chen Y, Li S, Yao X, Li H, Liu W, Zhang M, Zhang X, Chen L

OncoTargets and Therapy 2015, 8:735-744

Published Date: 7 April 2015

An efficient method for in vitro gene delivery via regulation of cellular endocytosis pathway

Luo J, Li C, Chen J, Wang G, Gao R, Gu Z

International Journal of Nanomedicine 2015, 10:1667-1678

Published Date: 2 March 2015

A three-dimensional electronic report of a venous echo color Doppler of the lower limbs: MEVeC®

Galeandro AI, Scicchitano P, Zito A, Galeandro C, Gesualdo M, Ciciarello F, Cecere A, Marzullo A, Contursi V, Annicchiarico A, Ciccone MM

Vascular Health and Risk Management 2014, 10:549-555

Published Date: 1 September 2014

Whole exome sequencing for cancer – is there evidence of clinical utility?

Malhotra A, Levine S, Allingham-Hawkins D

Advances in Genomics and Genetics 2014, 4:115-128

Published Date: 22 August 2014

Preparation of bufalin-loaded pluronic polyetherimide nanoparticles, cellular uptake, distribution, and effect on colorectal cancer

Hu Q, Liang B, Sun Y, Guo XL, Bao YJ, Xie DH, Zhou M, Duan YR, Yin PH, Peng ZH

International Journal of Nanomedicine 2014, 9:4035-4041

Published Date: 21 August 2014

The genomics and genetics of endometrial cancer

O'Hara AJ, Bell DW

Advances in Genomics and Genetics 2012, 2:33-47

Published Date: 6 March 2012

Current surgical status of thyroid diseases

Touzopoulos P, Karanikas M, Zarogoulidis P, Mitrakas A, Porpodis K, Katsikogiannis N, Zervas V, Kouroumichakis I, Constantinidis TC, Mikroulis D, Tsimogiannis KE

Journal of Multidisciplinary Healthcare 2011, 4:441-449

Published Date: 14 December 2011