Back to Journals » International Journal of Nanomedicine » Volume 8 » Issue 1

Toxic effects of the interaction of titanium dioxide nanoparticles with chemicals or physical factors

Authors Liu K, Lin X, Zhao J

Received 18 April 2013

Accepted for publication 15 May 2013

Published 18 July 2013 Volume 2013:8(1) Pages 2509—2520


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Kui Liu, Xialu Lin, Jinshun Zhao

Public Health Department of Medical School, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Ningbo University, Ningbo, Zhejiang Province, People’s Republic of China

Abstract: Due to their chemical stability and nonallergic, nonirritant, and ultraviolet protective properties, titanium dioxide (TiO2) nanoparticles (NPs) have been widely used in industries such as electronics, optics, and material sciences, as well as architecture, medicine, and pharmacology. However, increasing concerns have been raised in regards to its ecotoxicity and toxicity on the aquatic environment as well as to humans. Although insights have been gained into the effects of TiO2 NPs on susceptible biological systems, there is still much ground to be covered, particularly in respect of our knowledge of the effects of the interaction of TiO2 NPs with other chemicals or physical factors. Studies suggest that interactions of TiO2 NPs with other chemicals or physical factors may result in an increase in toxicity or adverse effects. This review highlights recent progress in the study of the interactive effects of TiO2 NPs with other chemicals or physical factors.

Keywords: titanium dioxide, TiO2, nanoparticles, interaction, chemicals, physical factors

Creative Commons License © 2013 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.