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Three Year Study of Infection Profile and Antimicrobial Resistance Pattern from Burn Patients in Southwest Iran

Authors Emami A, Pirbonyeh N, Keshavarzi A, Javanmardi F, Moradi Ghermezi S, Ghadimi T

Received 10 February 2020

Accepted for publication 29 April 2020

Published 20 May 2020 Volume 2020:13 Pages 1499—1506


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Suresh Antony

Amir Emami,1 Neda Pirbonyeh,1 Abdolkhalegh Keshavarzi,2 Fatemeh Javanmardi,1 Sedigheh Moradi Ghermezi,1 Tayyeb Ghadimi3

1Microbiology Department, Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; 2Surgery Department, Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; 3Burn Research Center, Surgery Department, Iran University of Medical Sciences, Tehran, Iran

Correspondence: Amir Emami
Microbiology Department, Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Introduction: Burn wound infections, as one of the most important risk factors, cause serious complications in burns. Hence, the focus of medical care should be preventing infections and resistant isolates. The current study investigates the prevalence of infectious agents and antimicrobial resistance patterns during three years.
Materials and Methods: A total of 960 isolates were collected from different sample kinds cultured for 615 burn patients who were hospitalized during January 2016 to December 2018 in Amir-Al-Momenin Burn Center. The type of microorganism and their antibiotic resistance patterns were identified by microbiological tests and the standard disk-diffusion method according to the introduced standard techniques.
Results: Incidence of positive growth was seen more in males than in females. Most of the burns encountered were due to flame injuries (35.4%). Based on the diversity of bacterial isolates, Pseudomonas aeruginosa was the most frequent pathogen (49.9%), followed by Klebsiella sp. (9.7%), Acinetobacter sp. (7.2%) and Staphylococcus aureus (6.5%). The trend of resistance of meropenem was declining in P. aeruginosa isolates. Klebsiella sp. as the second most prevalent agent showed a high level of resistance to the studied antibiotics. The antibiogram results for S. aureus isolates showed an increasing trend in MRSA isolates.
Conclusion: By evaluating the infectious agent, it was found that although frequencies of microorganisms and resistant isolates were a little high, performing a multidisciplinary approach controls the trend during the study period. These achievements have been gained due to a strict politicized infection control and stewardship program in the appointed burn center.

Keywords: nosocomial infections, antibiotic resistance pattern, burn

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