Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 10 » Issue 1

The stats are in: an update on statin use in COPD

Authors Carlson AA, Smith EA, Reid DJ

Received 11 June 2015

Accepted for publication 26 August 2015

Published 22 October 2015 Volume 2015:10(1) Pages 2277—2284

DOI https://doi.org/10.2147/COPD.S78875

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Professor Hsiao-Chi Chuang

Peer reviewer comments 2

Editor who approved publication: Dr Richard Russell

Alexa A Carlson,1 Ethan A Smith,2 Debra J Reid1

1Department of Pharmacy and Health System Sciences, School of Pharmacy, Northeastern University, Boston, MA, USA; 2Department of Pharmacy, Beth Israel Deaconess Medical Center, Boston, MA, USA

Abstract: COPD is a chronic inflammatory disease of the lungs associated with an abnormal inflammatory response to noxious particles, the most prevalent of which is cigarette smoke. Studies have demonstrated that cigarette smoking is associated with activation of the bone marrow, and chronic smoking can lead to the inflammatory changes seen in COPD. Due to the inflammatory nature of the disease, medications affecting the inflammatory pathway may have clinical benefit and are being evaluated. One such class of medications, HMG-CoA reductase inhibitors, have been evaluated in the COPD population. Early studies have suggested that HMG-CoA reductase inhibitors have a variety of benefits in COPD including improvements in inflammatory markers, exacerbation rates, and mortality rates. However, the majority of this data comes from retrospective cohort studies, suggesting the need for randomized controlled trials. Recently, two randomized controlled trials, STATCOPE and RODEO, evaluated the benefit of HMG-CoA reductase inhibitors in the COPD population and found no benefit in exacerbation rates and vascular or pulmonary function, respectively. These results are reflected in practice guidelines, which do not support the use of HMG-CoA reductase inhibitors for the purpose of reducing COPD exacerbations.

Keywords: chronic obstructive pulmonary disease, statins, HMG-CoA reductase inhibitors

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other article by this author:

Readers of this article also read:

Switching treatments in COPD: implications for costs and treatment adherence

Braido F, Lavorini F, Blasi F, Baiardini I, Canonica GW

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2601-2608

Published Date: 3 December 2015

Bacterial flora in the sputum and comorbidity in patients with acute exacerbations of COPD

Boixeda R, Almagro P, Díez-Manglano J, Cabrera FJ, Recio J, Martin-Garrido I, Soriano JB

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2581-2591

Published Date: 1 December 2015

Assessments of endothelial function and arterial stiffness are reproducible in patients with COPD

Rodriguez-Miguelez P, Seigler N, Bass L, Dillard TA, Harris RA

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1977-1986

Published Date: 16 September 2015

Does eosinophilic COPD exacerbation have a better patient outcome than non-eosinophilic in the intensive care unit?

Saltürk C, Karakurt Z, Adiguzel N, Kargin F, Sari R, Celik ME, Takir HB, Tuncay E, Sogukpinar O, Ciftaslan N, Mocin O, Gungor G, Oztas S

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1837-1846

Published Date: 8 September 2015

Anticancer activities of self-assembled molecular bowls containing a phenanthrene-based donor and Ru(II) acceptors

Kim I, Song YH, Singh N, Jeong YJ, Kwon JE, Kim H, Cho YM, Kang SC, Chi KW

International Journal of Nanomedicine 2015, 10:143-153

Published Date: 25 August 2015

Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients

Ferrari R, Caram LMO, Faganello MM, Sanchez FF, Tanni SE, Godoy I

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1553-1558

Published Date: 6 August 2015

Prognostic factors for clinical failure of exacerbations in elderly outpatients with moderate-to-severe COPD

Wilson R, Anzueto A, Miravitlles M, Arvis P, Haverstock D, Trajanovic M, Sethi S

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:985-993

Published Date: 2 June 2015