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The statistical analyses of the study “Sufentanil Sublingual Tablet System (SSTS) for the management of postoperative pain after major abdominal and gynecological surgery within an ERAS protocol: an observational study”[Letter]
Received 23 August 2019
Accepted for publication 30 August 2019
Published 12 September 2019 Volume 2019:12 Pages 2723—2724
DOI https://doi.org/10.2147/JPR.S228372
Checked for plagiarism Yes
Editor who approved publication: Dr Katherine Hanlon
Xiaohan Wang,1 Shuai Miao2
1Department of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of China; 2Department of Anesthesiology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, Jiangsu, People’s Republic of China
Correspondence: Shuai Miao
Department of Anesthesiology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, Jiangsu 214023, People’s Republic of China
Email [email protected]
We read the observational study “Sufentanil Sublingual Tablet System (SSTS) for the management of postoperative pain after major abdominal and gynecological surgery within an ERAS protocol: an observational study” of Stefano Turi et al.1 published in August 2019, Volume 12, p2313–2319 with great pleasure. I think that the findings detected in this study will contribute to the clinical practice. However, the statistical analyses were not appropriate.
View the original paper by Stefano Turi and colleagues
A Response to Letter has been published for this article.
Dear editor
We read the observational study “Sufentanil Sublingual Tablet System (SSTS) for the management of postoperative pain after major abdominal and gynecological surgery within an ERAS protocol: an observational study” of Stefano Turi et al.1 published in August 2019, Volume 12, p2313–2319 with great pleasure. I think that the findings detected in this study will contribute to the clinical practice. However, the statistical analyses were not appropriate.
In the "Data analysis" section, the authors stated that
"Pain intensity was calculated as the mean NRS value at first administration (baseline, V0), and during the following 24, 48, and 72 hrs (V1, V2, and V3, respectively). Pain intensity at different timepoints was compared using the Student’s t-test".
The effect of time should be considered by the authors to measure the NRS value at each pre-determined assessment time. Therefore, we think the pain intensity at different timepoints should be analyzed using a repeated-measures analysis.
Disclosure
The authors report no conflicts of interest in this communication.
Reference
1. Turi S, Deni F, Lombardi G, Marmiere M, Nisi FG, Beretta L. Sufentanil Sublingual Tablet System (SSTS) for the management of postoperative pain after major abdominal and gynecological surgery within an ERAS protocol: an observational study. J Pain Res. 2019;12:2313–2319. doi:10.2147/JPR.S191183
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