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The naked mole-rat as an animal model in biomedical research: current perspectives

Authors Schuhmacher L, Husson Z, Smith ESJ

Received 10 May 2015

Accepted for publication 30 June 2015

Published 11 August 2015 Volume 2015:7 Pages 137—148

DOI https://doi.org/10.2147/OAAP.S50376

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Peter Koulen


Laura-Nadine Schuhmacher, Zoé Husson, Ewan St. John Smith

Department of Pharmacology, University of Cambridge, Cambridge, UK

Abstract: The naked mole-rat (NMR) is a subterranean rodent that has gained significant attention from the biomedical research community in recent years as molecular mechanisms underlying its unusual biology start to be unraveled. With very low external mortality, NMRs have an unusually long lifespan while showing no signs of aging, such as neurodegeneration or cancer. Furthermore, living underground in large colonies (100 to 300 animals), results in comparatively high carbon dioxide and low oxygen levels, from which NMRs have evolved extreme resistance to both hypoxia and hypercapnia. In this paper we have summarized the latest developments in NMR research and its impact on biomedical research, with the aim of providing a sound background that will inform and inspire further investigations.

Keywords: naked mole-rat, longevity, cancer, hypoxia, nociception, pain

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