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The evaluation of the association between the metabolic syndrome and tumor grade and stage of bladder cancer in a Chinese population

Authors Sha N, Xu H, Chen T, Tian D, Xie W, Xie L, Zhang Y, Xing C, Liu X, Shen Z, Wu Z, Hu H, Wu C

Received 13 December 2015

Accepted for publication 9 February 2016

Published 7 March 2016 Volume 2016:9 Pages 1175—1179

DOI https://doi.org/10.2147/OTT.S102424

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ram Prasad

Peer reviewer comments 2

Editor who approved publication: Professor Min Li


Nan Sha,1,2,* Hao Xu,1,2,* Tao Chen,1,2,* Da-wei Tian,1,2 Wan-qin Xie,3 Lin-Guo Xie,1,2 Yu Zhang,1,2 Chen Xing,1,2 Xiao-teng Liu,1,2 Zhong-Hua Shen,1,2 Zhou-Liang Wu,1,2 Hai-Long Hu1,2 Chang-Li Wu1,2

1Department of Urology, The Second Hospital of Tianjin Medical University, 2Tianjin Key Laboratory of Urology, Tianjin Institute of Urology, Tianjin, 3Key Laboratory of Genetics and Birth Health of Hunan province, Family Planning Research Institute of Hunan Province, Changsha, Hunan, People’s Republic of China

*These authors contributed equally to this work

Objective: The objective of this article was to summarize the relationship between some components of metabolic syndrome (MetS) and the histopathologic findings in bladder cancer in a Chinese population.
Methods: We retrospectively analyzed data of 323 patients from the Department of Urology, Second Hospital of Tianjin Medical University between January 2012 and January 2014. All the patients were diagnosed with bladder cancer for the first time. Age, height, weight, histologic stage, grade, the presence of hypertension, diabetes mellitus, and body mass index were evaluated. The 2009 American Joint Committee on Cancer TNM staging system was used, with Ta and T1 tumors accepted as lower stage and T2, T3, and T4 tumors as higher stage bladder cancers. Also, pathologists assigned tumor grade according to the 1973 World Health Organization grading system. Noninvasive papillary urothelial neoplasms of low malignant potential were regarded as low grade. Analyses were completed using chi-square tests and logistic regression analysis.
Results: Of the 323 patients, 164 had hypertension, 151 had diabetes mellitus, and 213 had a body mass index ≥25 kg/m2. MetS was significantly associated with histologic grade (P<0.001) and stage (P=0.006) of bladder cancer. Adjusted for age in binary logistic regression analysis, the presence of MetS predicts the risk of higher T stage (odds ratio =4.029, P<0.001) and grade (odds ratio =3.870, P<0.001) of bladder cancer.
Conclusion: The patients with MetS in the People’s Republic of China were found to have statistically significant higher T stage and grade of bladder cancer.

Keywords: metabolic syndrome, primary carcinoma of the bladder, diabetes mellitus, hypertension, obesity, histologic grade and stage

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