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The Diagnostic Value of Serum Ferritin for Telogen Effluvium: A Cross-Sectional Comparative Study

Authors Cheng T, Fang H, Wang Y, Wang Y, Yang Z, Wu R, Yang D

Received 16 November 2020

Accepted for publication 18 January 2021

Published 10 February 2021 Volume 2021:14 Pages 137—141


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Jeffrey Weinberg

Tiantian Cheng,1,2 Huijuan Fang,1,2 Yongchao Wang,3 Ying Wang,2 Zhishan Yang,1,2 Ruiying Wu,1,2 Dingquan Yang2

1School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Department of Dermatology, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 3Department of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, People’s Republic of China

Correspondence: Dingquan Yang
Department of Dermatology, China-Japan Friendship Hospital, Beijing, People’s Republic of China
Tel +86 13901218671

Purpose: This study aimed to explore the relationship between serum ferritin levels and telogen effluvium.
Patients and Methods: A total of 193 telogen effluvium patients and 104 female androgenetic alopecia patients were included. We collected the test result of serum ferritin levels, compared with the results of 183 healthy subjects. Receiver Operator Characteristic curves were generated to assess the potential diagnostic value of serum ferritin in telogen effluvium patients.
Results: The serum ferritin in telogen effluvium patients were significantly lower than that in the healthy control group (P = 0.000) or female androgenetic alopecia patients (P =0.000). Patients with lower serum ferritin levels got high odds to have telogen effluvium. The areas under the Receiver Operator Characteristic curve of serum ferritin levels were 0.735 and 0.645 for distinguishing telogen effluvium patients from healthy control subjects or female androgenetic alopecia patients.
Conclusion: Serum ferritin could be a potential biomarker for clinical diagnosis of telogen effluvium.

Keywords: serum ferritin, telogen effluvium, female androgenetic alopecia, ROC curve

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