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The Copenhagen Oral Cavity Squamous Cell Carcinoma database: protocol and report on establishing a comprehensive oral cavity cancer database

Authors Schmidt Jensen J, Jakobsen KK, Mirian C, Christensen JT, Schneider K, Nahavandipour A, Wingstrand VL, Wessel I, Tvedskov JF, Frisch T, Christensen A, Specht L, Andersen E, Lelkaitis G, Grønhøj C, von Buchwald C

Received 11 May 2019

Accepted for publication 16 July 2019

Published 19 August 2019 Volume 2019:11 Pages 733—741


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Professor Irene Petersen

Jakob Schmidt Jensen,1 Kathrine Kronberg Jakobsen,1 Christian Mirian,1 Julie Thor Christensen,1 Katrine Schneider,1 Arvin Nahavandipour,1 Vibe Lindeblad Wingstrand,1 Irene Wessel,1 Jesper Filtenborg Tvedskov,1 Thomas Frisch,1 Anders Christensen,1 Lena Specht,2 Elo Andersen,3 Giedrius Lelkaitis,4 Christian Grønhøj,1 Christian von Buchwald1

1Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark; 2Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark; 3Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev 2730, Denmark; 4Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark

Correspondence: Christian von Buchwald
Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen 2100, Denmark
Tel +45 3 545 2370

Objective: The aim was to establish a large comprehensive database of patients with oral cavity squamous cell carcinoma (OSCC) to enable surveillance and research of the disease.
Methods: All patients diagnosed and/or treated for OSCC at Rigshospitalet, University of Copenhagen, Denmark in the period 2000–2014 were included. Rigshospitalet is a tertiary treatment center and covers the Eastern Denmark region, comprising nearly half of the approximately 5.8 million inhabitants of Denmark. Data on numerous variables regarding general information of the patients at diagnosis, their primary cancer, recurrence, treatment, prior cancers, and secondary cancers were collected from the Danish Pathology Register and by evaluation of medical charts.
Results: One thousand three hundred and ninety-nine OSCC patients were included in the database (62% males). The median age at diagnosis was 63 years (range: 23–99 years). The most common anatomical location was the floor of mouth (38%). Among patients with known stage, 70.0% were diagnosed in T-stage 1 or 2 and 64.9% were diagnosed in N-stage 0. Most patients were treated with primary surgery (81.7% among patients with known treatment), of these 44% received adjuvant radiotherapy after surgery. The overall age-standardized incidence of OSCC per 100,000 increased from 2.15 in 2000 to 3.04 in 2014, with a significant annual percent change of 3.2%.
Conclusion: We have established a consecutive, population-based database of 1,399 OSCC patients. This creates a basis for multiple studies that will elaborate our understanding of OSCC, and hopefully improve diagnosis, treatment, and rehabilitation of OSCC patients.

Keywords: head and neck cancer, oral cavity cancer, squamous cell carcinoma, OSCC, database, epidemiology

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