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Systemic inflammatory response syndrome and platelet count ≥250×109 are associated with venous thromboembolic disease

Authors Pate A, Baltazar G, Labana S, Bhagat T, Kim J, Chendrasekhar A

Received 5 August 2014

Accepted for publication 7 October 2014

Published 14 January 2015 Volume 2015:8 Pages 37—40

DOI https://doi.org/10.2147/IJGM.S72259

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Amy Pate, Gerard A Baltazar, Shahniwaz Labana, Trishul Bhagat, Joseph Kim, Akella Chendrasekhar

Richmond University Medical Center, Staten Island, NY, USA

Introduction: Prior research has demonstrated that platelet count and inflammation are dominant contributors to hypercoagulability. Our objective is to determine whether elevated platelet count and systemic inflammatory response syndrome (SIRS) have an association with the development of venous thromboembolism (VTE) in hospitalized patients with a high clinical index of suspicion for thromboembolic disease.
Methods: We performed a retrospective medical record review of 844 medical and surgical patients with suspected VTE hospitalized from July 2012 to May 2013 who underwent screening by venous duplex and computed tomography pulmonary angiogram. For our purposes, thrombocytosis was arbitrarily defined as platelet count ≥250×109/L.
Results: Venous thromboembolic disease was detected in 229 patients (25.9%). Thrombocytosis was present in 389 patients (44%) and SIRS was present in 203 patients (23%) around the time of imaging. Thrombocytosis and SIRS were positively correlated with VTE (P<0.001). There was no correlation between thrombocytosis and SIRS. Multivariate analysis revealed that SIRS (odds ratio 1.91, 95% confidence interval 1.36–2.68, P<0.001) and thrombocytosis (odds ration 1.67, 95% confidence interval 1.23–2.26, P=0.001) were independently associated with VTE.
Conclusion: Patients at high risk for VTE should be routinely assessed for thrombocytosis (≥250×109/L) and SIRS; if either is present, consideration for empiric anticoagulation should be given while diagnostic imaging is undertaken.

Keywords: SIRS, thrombocytosis, VTE, platelet count

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