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Systematic review comparing LABA, olodaterol, and indacaterol: limitations

Authors Donohue J

Received 23 September 2014

Accepted for publication 29 September 2014

Published 5 December 2014 Volume 2014:9(1) Pages 1331—1335


Checked for plagiarism Yes

Editor who approved publication: Dr Richard Russell

James F Donohue

Pulmonary Diseases and Critical Care Medicine, UNC School of Medicine, Chapel Hill, NC, USA

Dear editor

Roskell et al present a systematic review comparing the long-acting beta2 agonists (LABA), olodaterol, and indacaterol in the July edition of the International Journal of Chronic Obstructive Pulmonary Disease.1 The end-points compared for the two LABAs were: change from baseline in trough forced expiratory volume in 1 second (FEV1) at week 12; quality of life analyzed by change from baseline in St George’s Respiratory Quotient (SGRQ; total score and proportion of responders) at week 12; transition dyspnea index (TDI), analyzed by change from baseline at week 12; use of rescue medication, analyzed by change from baseline in average number of puffs per day; and proportion of patients experiencing at least one exacerbation, analyzed in trials with a treatment duration of 24 weeks or longer reporting data for this outcome. The authors conclude that olodaterol and indacaterol have similar efficacy in patients with COPD. 

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