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Synthesis, characterization, and antimicrobial evaluation of novel 5-benzoyl-N-substituted amino- and 5-benzoyl-N-sulfonylamino-4-alkylsulfanyl-2-pyridones

Authors Elgemeie G, Altalbawy F, Alfaidi M, Azab R, Hassan A

Received 21 August 2017

Accepted for publication 12 October 2017

Published 28 November 2017 Volume 2017:11 Pages 3389—3399


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Anastasios Lymperopoulos

Galal Elgemeie,1 Farag Altalbawy,2,3 Mohammed Alfaidi,3 Rania Azab,2,4 Atef Hassan5

1Department of Chemistry, Faculty of Science, Helwan University, Helwan, 2National Institute of Laser Enhanced Sciences (NILES), Cairo University, Giza, Egypt; 3Department of Biological Sciences, University College of Duba, Tabuk University, Tabuk, 4Department of Biological Sciences, Faculty of Science, Al-Baha University, Al-Baha, Saudi Arabia; 5Department of Mycology and Mycotoxins, Animal Health Research Institute, Agriculture Research Center, Giza, Egypt

Abstract: The present research describes the synthesis of novel 5-benzoyl-N-substituted-amino- and 5-benzoyl-N-sulfonylamino-4-alkylsulfanyl-2-pyridones 5a–c and 6a–c via the reaction of 2-benzoyl-3,3-bis(alkylthio)acrylonitriles 2a–c with N-cyanoacetohydrazide 3 and cyanoaceto-N-phenylsulfonylhydrazide 4, respectively. Also, the reactivity of the compounds 5a–c toward hydrazine hydrate to give product 1H-pyrazolo[4,3-c]pyridine derivative 7 was studied. In addition, the reactivity of the 2a–c toward 1-cyanoacetyl-4 arylidenesemicarbazides 8a–c afforded 3,5-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitrile derivatives (12–14)a–c, which reacted with hydrazine hydrate to give 3H-pyrazolo[4,3-c][1,2,4]triazolo[1,5-a]pyridine-6-carbonitrile derivatives 15a–c. The structures of the new products were characterized based on 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, infrared, mass-spectroscopy, and elemental analyses. The products were screened in vitro for their antibacterial and antifungal activity properties.

Keywords: amino-2-pyridones, N-cyanoacetohydrazide, cyanoaceto-N-phenylsulfonylhydrazide, 2-benzoyl-3,3-bis(alkylthio)acrylonitriles, 5-benzoyl-N-sulfonylamino-4-alkylsulfanyl-2-pyridones, 5-benzoyl-N-substituted-amino-4-alkylsulfanyl-2 pyridones, antimicrobial activity

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